2-(4-methoxyphenyl)-3-oxo-4-phenylbutanenitrile

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-3-oxo-4-phenylbutanenitrile
• CAS No.: 1129306-71-3
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.312
• Mol file: 1129306-71-3.mol

Synonyms:2-(4-methoxyphenyl)-3-oxo-4-phenylbutanenitrile

Chemical Property of 2-(4-methoxyphenyl)-3-oxo-4-phenylbutanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxyphenyl)-3-oxo-4-phenylbutanenitrile

There total 1 articles about 2-(4-methoxyphenyl)-3-oxo-4-phenylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-methoxy-N-methyl-2-phenylacetamide (95092-10-7) + p-methoxybenzylnitrile (104-47-2) → 2-(4-methoxyphenyl)-3-oxo-4-phenylbutanenitrile (1129306-71-3)

Guidance literature:

p-methoxybenzylnitrile; With methyllithium; lithium bromide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.5h; Inert atmosphere;

N-methoxy-N-methyl-2-phenylacetamide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1.5h; Inert atmosphere;

DOI:10.1039/c4ob02398f

Reference yield: 64.0%

2-(4-methoxyphenyl)-3-oxo-4-phenylbutanenitrile (1129306-71-3) + N-aminophthalamide (1875-48-5) → (E)-3-(1,3-dioxoisoindolin-2-ylimino)-2-(4-methoxy-phenyl)-4-phenylbutanenitrile

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 7h; Molecular sieve; Inert atmosphere; Reflux;

DOI:10.1039/c1ob05069a

Reference yield:

2-(4-methoxyphenyl)-3-oxo-4-phenylbutanenitrile (1129306-71-3) + N-aminophthalamide (1875-48-5) → 2-benzyl-1-(1,3-dioxoisoindolin-2-yl)-6-methoxy-1H-indole-3-carbonitrile (1310370-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 7 h / Molecular sieve; Inert atmosphere; Reflux

2: ferric(III) bromide / 1,2-dichloro-ethane / 2.5 h / 20 °C / Inert atmosphere

With ferric(III) bromide; toluene-4-sulfonic acid; In 1,2-dichloro-ethane; toluene;

DOI:10.1039/c1ob05069a

upstream raw materials:

N-methoxy-N-methyl-2-phenylacetamide

p-methoxybenzylnitrile

Downstream raw materials:

2-benzyl-1-(1,3-dioxoisoindolin-2-yl)-6-methoxy-1H-indole-3-carbonitrile

Refernces