95092-10-7

Basic information

• Product Name: N-Methoxy-N-Methyl-2-phenylacetaMide
• Synonyms: N-Methoxy-N-Methyl-2-phenylacetaMide;N-methoxy-N-methylbenzeneacetamide
• CAS NO: 95092-10-7
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.21572
• EINECS: -0
• Mol File: 95092-10-7.mol
• Article Data: 66

Chemical Properties

• Boiling Point: 254.0±33.0 °C(Predicted)
• Appearance: /
• Density: 1.079±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-Methoxy-N-Methyl-2-phenylacetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methoxy-N-Methyl-2-phenylacetaMide(95092-10-7)
• EPA Substance Registry System: N-Methoxy-N-Methyl-2-phenylacetaMide(95092-10-7)

Safety Data

• Hazardous Substances Data: 95092-10-7(Hazardous Substances Data)

Usage

General Description

N-Methoxy-N-Methyl-2-phenylacetamide is a chemical compound that is commonly used as a pharmaceutical intermediate in the synthesis of various drugs. It is a white to off-white crystalline powder that is soluble in organic solvents such as ethanol and acetone. N-Methoxy-N-Methyl-2-phenylacetaMide is widely used in the pharmaceutical industry for its analgesic and antipyretic properties. It is also used as a precursor in the synthesis of other pharmaceutical compounds. However, it is important to handle this chemical with care as it can be hazardous if not properly managed.

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 101-41-7 benzeneacetic acid methyl ester 
• 103-80-0 phenylacetyl chloride 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 103-82-2 phenylacetic acid 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 1062512-43-9 C₆H₁₈N₃O₃P 
• 201230-82-2 carbon monoxide 
• 100-44-7 benzyl chloride 
• 536-74-3 phenylacetylene 
• 140-29-4 phenylacetonitrile 
• 1867-37-4 Benzylmalononitrile 
• 100-52-7 benzaldehyde 
• 2700-22-3 Benzylidenemalononitrile 

Downstream Products

• 138343-84-7 [2-(2-Oxo-3-phenyl-propyl)-phenyl]-carbamic acid tert-butyl ester 
• 18753-56-5 3-Phenyl-5-(phenylmethyl)isoxazole 
• 6683-92-7 1-phenylpentan-2-one 
• 1070668-14-2 1-[2-(tert-butoxycarbonylaminomethyl)-6-chlorophenyl]-3-phenyl-2-propanone 
• 1238323-41-5 1-[4-(1-azido-1-methylethyl)phenyl]-2-phenylethanone 
• 220753-43-5 2-Phenyl-1-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-ethanone 
• 220753-45-7 2-Phenyl-1-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]-ethanone 
• 220753-47-9 1-(2-benzothiazolyl)-2-phenyl-1-ethanone 
• 1355999-87-9 5-[4-(2-bromo-2-phenyl-acetyl)-phenyl]-2-oxa-4-aza-bicyclo[3.1.1]heptan-3-one 
• 1355999-88-0 5-[4-(7-methoxy-3-phenyl-imidazo[1,2-a]pyrimidin-2-yl)-phenyl]-2-oxa-4-aza-bicyclo[3.1.1]heptan-3-one 
• 1355999-86-8 5-(4-phenylacetyl-phenyl)-2-oxa-4-aza-bicyclo[3.1.1]heptan-3-one 
• 1129306-71-3 2-(4-methoxyphenyl)-3-oxo-4-phenylbutanenitrile 
• 19212-27-2 3-oxo-4-phenylbutyronitrile 

Relevant articles and documents

Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water

Host-guest assemblies of a designed 1,4-bis(diarylamino)naphthalene and V-shaped aromatic amphiphiles consisting of two pentamethylbenzene moieties bridged by an m -phenylene unit bearing two hydrophilic side chains emerged as highly reducing photoredox catalysis systems in water. An efficient demethoxylative hydrogen transfer of Weinreb amides has been developed. The present supramolecular strategy permits facile tuning of visible-light photoredox catalysis in water.

Catalytic α-Deracemization of Ketones Enabled by Photoredox Deprotonation and Enantioselective Protonation

This study reports the catalytic deracemization of ketones bearing stereocenters in the α-position in a single reaction via deprotonation, followed by enantioselective protonation. The principle of microscopic reversibility, which has previously rendered this strategy elusive, is overcome by a photoredox deprotonation through single electron transfer and subsequent hydrogen atom transfer (HAT). Specifically, the irradiation of racemic pyridylketones in the presence of a single photocatalyst and a tertiary amine provides nonracemic carbonyl compounds with up to 97% enantiomeric excess. The photocatalyst harvests the visible light, induces the redox process, and is responsible for the asymmetric induction, while the amine serves as a single electron donor, HAT reagent, and proton source. This conceptually simple light-driven strategy of coupling a photoredox deprotonation with a stereocontrolled protonation, in conjunction with an enrichment process, serves as a blueprint for other deracemizations of ubiquitous carbonyl compounds.

Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of α,β-Unsaturated Carbonyl Compounds

Azidation of alkenes is an efficient protocol to synthesize organic azides which are important structural motifs in organic synthesis. Enantioselective radical azidation, as a useful strategy to install a C-N3 bond, remains challenging due to the inherently instability and unique structure of radicals. Here, we disclose an efficient enantioselective radical carboazidation and diazidation of α,β-unsaturated ketones and amides catalyzed by chiral N,N′-dioxide/Fe(OTf)2 complexes. An array of substituted alkenes was transformed to the corresponding α-azido carbonyl derivatives in good to excellent enantioselectivities, benefiting the preparation of chiral α-amino ketones, vicinal amino alcohols, and vicinal diamines. Control experiments and mechanistic studies proved the radical pathway in the reaction process. The DFT calculations showed that the azido transferred to the radical intermediate via an intramolecular five-membered transition state with the internal nitrogen of the Fe-N3 species.