(R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine

Base Information

Chemical Name:(R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine
CAS No.:1383742-56-0
Molecular Formula:C₂₆H₂₂FN₅
Molecular Weight:423.493
Hs Code.:

Synonyms:(R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine

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Technology Process of (R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine

There total 1 articles about (R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1013-88-3
Benzophenone imine

: 1383742-42-4
(R)-6-(5-bromo-2-fluorophenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-amine

: 1383742-56-0
(R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 2h; Inert atmosphere; sealed tube;

Reference yield:

: 1383742-56-0
(R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine

: 1383742-57-1
(R)-6-(5-amino-2-fluorophenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-amine

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; at 20 ℃; for 2h;

Reference yield:

: 1383742-56-0
(R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine

: 1383741-31-8
(R)-5-chloro-pyridine-2-carboxylic acid [3-(8-amino-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 2 h / 20 °C

2.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h / 20 °C

2.2: 3 h / 0 - 20 °C

With hydrogenchloride; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; water; isopropyl alcohol;