(R)-6-(5-amino-2-fluorophenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-amine

Base Information

Chemical Name:(R)-6-(5-amino-2-fluorophenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-amine
CAS No.:1383742-57-1
Molecular Formula:C₁₃H₁₄FN₅
Molecular Weight:259.286
Hs Code.:

Synonyms:(R)-6-(5-amino-2-fluorophenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-6-(5-amino-2-fluorophenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-amine

Chemical Property:

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Technology Process of (R)-6-(5-amino-2-fluorophenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-amine

There total 6 articles about (R)-6-(5-amino-2-fluorophenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383742-56-0
(R)-6-[5-(benzhydrylidene-amino)-2-fluoro-phenyl]-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine

: 1383742-57-1
(R)-6-(5-amino-2-fluorophenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-amine

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; at 20 ℃; for 2h;

Reference yield:

: 1383742-21-9
t-butyl (R)-(2-(5-bromo-2-fluorophenyl)-1-(2-cyano-1H-imidazol-1-yl)propan-2-yl)carbamate

: 1383742-57-1
(R)-6-(5-amino-2-fluorophenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 4 h / 70 °C

2: sodium azide; copper(l) iodide; sodium carbonate; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 110 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; sodium azide; sodium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; dimethyl sulfoxide;
DOI:10.1021/acsmedchemlett.9b00181

Reference yield:

: 1228571-14-9
(2R)-2-amino-2-(5-bromo-2-fluorophenyl)propan-1-ol

: 1383742-57-1
(R)-6-(5-amino-2-fluorophenyl)-6-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-8-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

2.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

2.2: 64 h / -40 - 20 °C / Inert atmosphere

3.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 2 h / 0 - 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 90 °C

5.1: hydrogenchloride / 1,4-dioxane / 4 h / 70 °C

6.1: sodium azide; copper(l) iodide; sodium carbonate; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 110 °C / Inert atmosphere

With hydrogenchloride; ruthenium trichloride; sodium periodate; copper(l) iodide; thionyl chloride; sodium azide; sodium hydrogencarbonate; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00181