4-(6-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butyrohydroxamic acid

Base Information

• Chemical Name: 4-(6-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butyrohydroxamic acid
• CAS No.: 1221962-24-8
• Molecular Formula: C₁₇H₁₅Cl₂N₃O₂
• Molecular Weight: 364.231
• Mol file: 1221962-24-8.mol

Synonyms:4-(6-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butyrohydroxamic acid

Chemical Property of 4-(6-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butyrohydroxamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(6-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butyrohydroxamic acid

There total 4 articles about 4-(6-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butyrohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(5-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid hydrochloride (1221961-86-9) → 4-(6-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butyrohydroxamic acid (1221962-24-8)

Guidance literature:

4-(5-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid hydrochloride; With acetic anhydride; for 1h; Reflux;

With hydroxylamine hydrochloride; sodium ethanolate; In ethanol; for 1h; Reflux;

With water; In ethanol; at 20 ℃;

Reference yield:

7-chloro-3-(4-chlorophenyl)-3,4-dihydropyrido[1,2-a]benzimidazol-1(2H)-one + 8-chloro-3-(4-chlorophenyl)-3,4-dihydropyrido[1,2-a]benzimidazol-1(2H)-one → 4-(5-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butyrohydroxamic acid (1221962-24-8)

Guidance literature:

7-chloro-3-(4-chlorophenyl)-3,4-dihydropyrido[1,2-a]benzimidazol-1(2H)-one; 8-chloro-3-(4-chlorophenyl)-3,4-dihydropyrido[1,2-a]benzimidazol-1(2H)-one; With hydroxylamine hydrochloride; In ethanol; Heating; Reflux;

With sodium ethanolate; In ethanol; for 1h; Reflux;

Reference yield:

3-(4-chlorophenyl)pentane-1,5-dioic acid (35271-74-0) → 4-(6-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butyrohydroxamic acid (1221962-24-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetyl chloride / 2 h / Reflux

2.1: 1,4-dioxane / 1 h / 20 °C

2.2: 2 h / Reflux

3.1: acetic anhydride / 1 h / Reflux

3.2: 1 h / Reflux

3.3: 20 °C

With acetic anhydride; acetyl chloride; In 1,4-dioxane;

upstream raw materials:

3-(4-chlorophenyl)glutaric anhydride

3-(4-chlorophenyl)pentane-1,5-dioic acid

4-(5-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid hydrochloride

Refernces

• 1、 -. "ALLOSTERIC PROTEIN KINASE MODULATORS". Page/Page column 69. . Retrieved 2010/04/30.