35271-74-0

Basic information

• Product Name: 3-(4-Chlorophenyl)glutaric acid
• Synonyms: 3-(4-CHLOROPHENYL)-PENTANEDIOIC ACID;3-(4-CHLOROPHENYL)GLUTARIC ACID;CBI-BB ZERO/006271;BETA-(4-CHLOROPHENYL)GLUTARIC ACID;B-(4-CHLOROPHENYL) GLUTARIC ACID;-(4-Chlorophenyl)glutaricacid;3-(4-chlorophenyl) glutarate;b-(p-Chlorophenyl)glutaric Acid
• CAS NO: 35271-74-0
• Molecular Formula: C₁₁H₁₁ClO₄
• Molecular Weight: 242.66
• EINECS: 252-477-1
• Product Categories: Miscellaneous Biochemicals;(intermediate of baclofen);Aromatics;Raw material
• Mol File: 35271-74-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 164-166°C
• Boiling Point: 394.4 °C at 760 mmHg
• Flash Point: 192.3 °C
• Appearance: White Solid
• Density: 1.396 g/cm³
• Vapor Pressure: 6.29E-07mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Soluble in dimethyl sulfoxide. Slightly soluble in methanol.
• PKA: 4.01±0.10(Predicted)
• BRN: 1976828
• CAS DataBase Reference: 3-(4-Chlorophenyl)glutaric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Chlorophenyl)glutaric acid(35271-74-0)
• EPA Substance Registry System: 3-(4-Chlorophenyl)glutaric acid(35271-74-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 35271-74-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

3-(4-Chlorophenyl)glutaric Acid (cas# 35271-74-0) is a compound useful in organic synthesis. Baclofen Impurity 1

InChI:InChI=1/C11H11ClO4/c12-9-3-1-7(2-4-9)8(5-10(13)14)6-11(15)16/h1-4,8H,5-6H2,(H,13,14)(H,15,16)/p-2

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 104-88-1 4-chlorobenzaldehyde 
• 137310-14-6 trimethyl 2-(4-chlorophenyl)propane-1,1,3-tricarboxylate 
• 20754-21-6 methyl 3-(4-chlorophenyl)propenoate 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 141-97-9 ethyl acetoacetate 
• 19411-80-4 2-(4-chlorophenylmethylene)acetoacetic acid ethyl ester 
• 84803-73-6 C₁₉H₂₃ClO₆ 
• 101104-10-3 diethyl 3-(4-chlorophenyl)glutarate 

Downstream Products

• 53911-68-5 3-(4-chlorophenyl)glutaric anhydride 
• 1187926-98-2 4-(4-chlorophenyl)tetrahydro-2H-pyran 
• 84803-46-3 4-(4-chlorophenyl)piperidine-2,6-dione 
• 1141-23-7 3-(p-chlorophenyl)glutaramic acid 
• 1134-47-0 4-amino-3-(4-chlorophenyl)butanoic acid 
• 1312809-16-7 4-(4-chlorophenyl)-1-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]piperidine-2,6-dione 
• 1312809-15-6 4-(4-chlorophenyl)-1-[3-[4-(2-chlorophenyl)piperazin-1-yl]propyl]piperidine-2,6-dione 
• 1312809-14-5 4-(4-chlorophenyl)-1-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]piperidine-2,6-dione 
• 1312809-13-4 4-(4-chlorophenyl)-1-[2-[4-(2-chlorophenyl)piperazin-1-yl]ethyl]piperidine-2,6-dione 
• 1312809-12-3 4-(4-chlorophenyl)-1-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]piperidine-2,6-dione 
• 1312808-98-2 1-(4-chlorobutyl)-4-(4-chlorophenyl)piperidine-2,6-dione 
• 1312808-97-1 4-(4-chlorophenyl)-1-(3-chloropropyl)piperidine-2,6-dione 
• 1312808-93-7 1-(2-chloroethyl)-4-(4-chlorophenyl)piperidine-2,6-dione 
• 1312808-91-5 4-(4-chlorophenyl)-1-(2-hydroxyethyl)piperidine-2,6-dione 

Relevant articles and documents

Hydrogen-Bonding Catalyzed Ring-Closing C?O/C?O Metathesis of Aliphatic Ethers over Ionic Liquid under Metal-Free Conditions

O-heterocycles have wide applications, and their efficient and green synthesis is very interesting. Herein, we report hydrogen-bonding catalyzed ring-closing metathesis of aliphatic ethers to O-heterocycles over ionic liquid (IL) catalyst under metal- and solvent-free conditions. The IL 1-butylsulfonate-3-methylimidazolium trifluoromethanesulfonate ([SO3H-BMIm][OTf]) is discovered to show outstanding performance, better than the reported catalysts. An interface effect plays an important role in mediating the reaction rate due to the immiscibility between the products and the IL catalyst, and the products can be spontaneously separated. NMR analysis and DFT calculation suggest that a pair of cation and anion of [SO3H-BMIm][OTf] could form three strong H-bonds with an ether molecule, which catalyze the ether transformation via a cyclic oxonium intermediate. A series of O-heterocycles including tetrahydrofurans, tetrahydropyrans, morpholines and dioxane can be obtained from their corresponding ethers in excellent yields (e.g., >99 %). This work opens an efficient and metal-free way to produce O-heterocycles from aliphatic ethers.

CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS

The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (IIIQ): wherein X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85', and z86' are as defined herein; or salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway. Accordingly, invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Synthesis and biological evaluation of pentanedioic acid derivatives as farnesyltransferase inhibitors

Structure-based virtual screening of a commercial library identified pentanedioic acid derivatives (6 and 13b) as a kind of novel scaffold farnesyltransferase inhibitors (FTIs). Chemical modifications of the lead compounds, biological assays and analysis of the structure-activity relationships (SAR) were conducted to discover more potent FTIs. Some of them displayed excellent inhibition against FTase, and among them, the most active compound 13n with an IC50 value of 0.0029 μM and SAR analysis might be helpful to the discovery of more potent FTIs. This journal is