N-(2-Allyloxy-9-{(2R,5S,6R)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-9H-purin-6-yl)-benzamide

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Chemical Name:N-(2-Allyloxy-9-{(2R,5S,6R)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-9H-purin-6-yl)-benzamide
CAS No.:207674-27-9
Molecular Formula:C₄₂H₄₁N₅O₇
Molecular Weight:727.817
Hs Code.:

Synonyms:N-(2-Allyloxy-9-{(2R,5S,6R)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-9H-purin-6-yl)-benzamide

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Chemical Property of N-(2-Allyloxy-9-{(2R,5S,6R)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-9H-purin-6-yl)-benzamide

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Technology Process of N-(2-Allyloxy-9-{(2R,5S,6R)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-9H-purin-6-yl)-benzamide

There total 7 articles about N-(2-Allyloxy-9-{(2R,5S,6R)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-9H-purin-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 207674-18-8
N-[2-Allyloxy-9-((2R,5S,6R)-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-9H-purin-6-yl]-benzamide

: 207674-27-9
N-(2-Allyloxy-9-{(2R,5S,6R)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: With tetrabutylammonium perchlorate; In pyridine; for 1h; Ambient temperature;
DOI:10.1002/hlca.19980810302

Reference yield:

: 145593-73-3
(+)-[(2R,3S,6S)-2-(benzoyloxymethyl)-6-methoxyoxan-3-yl] benzoate

: 207674-27-9
N-(2-Allyloxy-9-{(2R,5S,6R)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / N,O-bis(trimethylsilyl)acetamide, trimethylsilyl trifluoromethanesulfonate / acetonitrile / 5 h / 65 °C

2: 78 percent / NH₃ / methanol / 6 h / 80 °C

3: 89 percent / Na / 2 h / 65 °C

4: pyridine / 17 h / Ambient temperature

5: NaOH / pyridine; H₂O; methanol / 1.17 h / 0 °C

6: 89 percent / (Bu₄N)ClO₄ / pyridine / 1 h / Ambient temperature

With sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; tetrabutylammonium perchlorate; ammonia; sodium; In pyridine; methanol; water; acetonitrile;
DOI:10.1002/hlca.19980810302

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 207674-27-9
N-(2-Allyloxy-9-{(2R,5S,6R)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / N,O-bis(trimethylsilyl)acetamide, trimethylsilyl trifluoromethanesulfonate / acetonitrile / 5 h / 65 °C

2: 78 percent / NH₃ / methanol / 6 h / 80 °C

3: 89 percent / Na / 2 h / 65 °C

4: pyridine / 17 h / Ambient temperature

5: NaOH / pyridine; H₂O; methanol / 1.17 h / 0 °C

6: 89 percent / (Bu₄N)ClO₄ / pyridine / 1 h / Ambient temperature

With sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; tetrabutylammonium perchlorate; ammonia; sodium; In pyridine; methanol; water; acetonitrile;
DOI:10.1002/hlca.19980810302