N-[2-Allyloxy-9-((2R,5S,6R)-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-9H-purin-6-yl]-benzamide

Base Information

Chemical Name:N-[2-Allyloxy-9-((2R,5S,6R)-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-9H-purin-6-yl]-benzamide
CAS No.:207674-18-8
Molecular Formula:C₂₁H₂₃N₅O₅
Molecular Weight:425.444
Hs Code.:

Synonyms:N-[2-Allyloxy-9-((2R,5S,6R)-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-9H-purin-6-yl]-benzamide

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Chemical Property of N-[2-Allyloxy-9-((2R,5S,6R)-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-9H-purin-6-yl]-benzamide

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Technology Process of N-[2-Allyloxy-9-((2R,5S,6R)-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-9H-purin-6-yl]-benzamide

There total 6 articles about N-[2-Allyloxy-9-((2R,5S,6R)-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-9H-purin-6-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₂H₃₅N₅O₈

: 207674-18-8
N-[2-Allyloxy-9-((2R,5S,6R)-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: With sodium hydroxide; In pyridine; methanol; water; at 0 ℃; for 1.16667h; Yield given;
DOI:10.1002/hlca.19980810302

Reference yield:

: 145593-73-3
(+)-[(2R,3S,6S)-2-(benzoyloxymethyl)-6-methoxyoxan-3-yl] benzoate

: 207674-18-8
N-[2-Allyloxy-9-((2R,5S,6R)-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / N,O-bis(trimethylsilyl)acetamide, trimethylsilyl trifluoromethanesulfonate / acetonitrile / 5 h / 65 °C

2: 78 percent / NH₃ / methanol / 6 h / 80 °C

3: 89 percent / Na / 2 h / 65 °C

4: pyridine / 17 h / Ambient temperature

5: NaOH / pyridine; H₂O; methanol / 1.17 h / 0 °C

With sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; ammonia; sodium; In pyridine; methanol; water; acetonitrile;
DOI:10.1002/hlca.19980810302

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 207674-18-8
N-[2-Allyloxy-9-((2R,5S,6R)-5-hydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / N,O-bis(trimethylsilyl)acetamide, trimethylsilyl trifluoromethanesulfonate / acetonitrile / 5 h / 65 °C

2: 78 percent / NH₃ / methanol / 6 h / 80 °C

3: 89 percent / Na / 2 h / 65 °C

4: pyridine / 17 h / Ambient temperature

5: NaOH / pyridine; H₂O; methanol / 1.17 h / 0 °C

With sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; ammonia; sodium; In pyridine; methanol; water; acetonitrile;
DOI:10.1002/hlca.19980810302