4-fluoro-2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazole

Base Information

• Chemical Name: 4-fluoro-2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazole
• CAS No.: 1013084-53-1
• Molecular Formula: C₂₂H₁₅F₄NO
• Molecular Weight: 385.361
• Mol file: 1013084-53-1.mol

Synonyms:4-fluoro-2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazole

Chemical Property of 4-fluoro-2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-fluoro-2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazole

There total 3 articles about 4-fluoro-2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

Benzophenone imine (1013-88-3) + dibromodifluoromethane (75-61-6) + 2,2,2-Trifluoroacetophenone (434-45-7) → benzophenone (119-61-9) + 4-fluoro-2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazole (1013084-53-1)

Guidance literature:

Benzophenone imine; dibromodifluoromethane; 2,2,2-Trifluoroacetophenone; With lead; tetrabutylammomium bromide; In dichloromethane; at 30 - 40 ℃; Sonication;

With water; silica gel; regioselective reaction;

DOI:10.1007/s11172-008-0136-2

Reference yield: 66.0%

Benzophenone imine (1013-88-3) + dibromodifluoromethane (75-61-6) + 2,2,2-Trifluoroacetophenone (434-45-7) → 4-fluoro-2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazole (1013084-53-1)

Guidance literature:

With lead; tetrabutylammomium bromide; In dichloromethane; at 40 ℃; for 6h; sonification;

DOI:10.1016/j.tetlet.2007.12.037

Reference yield:

Benzophenone imine (1013-88-3) + dibromodifluoromethane (75-61-6) + 2,2,2-Trifluoroacetophenone (434-45-7) → benzophenone (119-61-9) + N-(diphenylmethylene)difluoromethanamine (1222313-43-0) + 4-fluoro-2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazole (1013084-53-1)

Guidance literature:

With lead; tetrabutylammomium bromide; In dichloromethane; at 40 ℃; for 42h; Title compound not separated from byproducts.; sonification;

DOI:10.1016/j.tetlet.2007.12.037

upstream raw materials:

Benzophenone imine

dibromodifluoromethane

2,2,2-Trifluoroacetophenone

Downstream raw materials:

[2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazol-4-yl]morpholine

2,2,5-triphenyl-5-(trifluoromethyl)oxazolidin-4-one

4-methoxy-2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazole

methyl 2-[2,2,5-triphenyl-5-(trifluoromethyl)-2,5-dihydro-1,3-oxazol-4-ylamino]acetate