(Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylate choline

Base Information

Chemical Name:(Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylate choline
CAS No.:1257792-63-4
Molecular Formula:C₅H₁₄NO*C₂₅H₂₁N₄O₅
Molecular Weight:561.638
Hs Code.:

(Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylate choline

Synonyms:(Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylate choline

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Chemical Property of (Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylate choline

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Technology Process of (Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylate choline

There total 11 articles about (Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylate choline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 62-49-7
choline

: 1257792-41-8
(Z)-5-(2-hydroxy-3-{2-[-3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-4(5H)-1H-pyrazol-4-ylidene]hydrazin-1-yl}phenyl)furan-2-carboxylic acid

: 1257792-63-4
(Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylate choline

Guidance literature:: In methanol; ethanol; water; ethyl acetate; at 20 - 40 ℃; for 75h;

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 1257792-63-4
(Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylate choline

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium nitrate; sulfuric acid / water / 2 h / 20 - 25 °C

2.1: potassium carbonate / acetone / 40 h / 70 °C

3.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / etheroxalic acid dimethyl ether / 17 h / Reflux

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / Reflux

4.2: pH 3

5.1: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 3.5 h / Reflux

6.1: boron tribromide / dichloromethane / 1 h / 20 °C

6.2: 1 h

7.1: hydrogenchloride; sodium nitrite / water / 0.33 h / Cooling with ice

7.2: 20 °C / pH 8 - 9 / Cooling with ice

7.3: pH 3 - 4

8.1: ethyl acetate; ethanol; water; methanol / 75 h / 20 - 40 °C

With hydrogenchloride; sodium nitrate; sulfuric acid; ammonium formate; potassium acetate; boron tribromide; sodium carbonate; potassium carbonate; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; etheroxalic acid dimethyl ether; water; ethyl acetate; acetone;

Reference yield:

: 13073-25-1
2-bromo-6-nitro-phenol

: 1257792-63-4
(Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylate choline

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 40 h / 70 °C

2.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / etheroxalic acid dimethyl ether / 17 h / Reflux

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / Reflux

3.2: pH 3

4.1: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 3.5 h / Reflux

5.1: boron tribromide / dichloromethane / 1 h / 20 °C

5.2: 1 h

6.1: hydrogenchloride; sodium nitrite / water / 0.33 h / Cooling with ice

6.2: 20 °C / pH 8 - 9 / Cooling with ice

6.3: pH 3 - 4

7.1: ethyl acetate; ethanol; water; methanol / 75 h / 20 - 40 °C

With hydrogenchloride; ammonium formate; potassium acetate; boron tribromide; sodium carbonate; potassium carbonate; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; etheroxalic acid dimethyl ether; water; ethyl acetate; acetone;