(Z)-5-(2-hydroxy-3-{2-[-3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-4(5H)-1H-pyrazol-4-ylidene]hydrazin-1-yl}phenyl)furan-2-carboxylic acid

Base Information

Chemical Name:(Z)-5-(2-hydroxy-3-{2-[-3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-4(5H)-1H-pyrazol-4-ylidene]hydrazin-1-yl}phenyl)furan-2-carboxylic acid
CAS No.:1257792-41-8
Molecular Formula:C₂₅H₂₂N₄O₅
Molecular Weight:458.473
Hs Code.:

Synonyms:(Z)-5-(2-hydroxy-3-{2-[-3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-4(5H)-1H-pyrazol-4-ylidene]hydrazin-1-yl}phenyl)furan-2-carboxylic acid

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Chemical Property of (Z)-5-(2-hydroxy-3-{2-[-3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-4(5H)-1H-pyrazol-4-ylidene]hydrazin-1-yl}phenyl)furan-2-carboxylic acid

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Technology Process of (Z)-5-(2-hydroxy-3-{2-[-3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-4(5H)-1H-pyrazol-4-ylidene]hydrazin-1-yl}phenyl)furan-2-carboxylic acid

There total 10 articles about (Z)-5-(2-hydroxy-3-{2-[-3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-4(5H)-1H-pyrazol-4-ylidene]hydrazin-1-yl}phenyl)furan-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.8%

: 109688-65-5
5-methyl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-2,4-dihydropyrazol-3-one

: 1257792-70-3
5-(3-amino-2-hydroxy-phenyl)-furan-2-carboxylic acid hydrobromide

: 1257792-41-8
(Z)-5-(2-hydroxy-3-{2-[-3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-4(5H)-1H-pyrazol-4-ylidene]hydrazin-1-yl}phenyl)furan-2-carboxylic acid

Guidance literature:: 5-(3-amino-2-hydroxy-phenyl)-furan-2-carboxylic acid hydrobromide; With hydrogenchloride; sodium nitrite; In water; for 0.333333h; Cooling with ice;

5-methyl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-2,4-dihydropyrazol-3-one; With sodium hydrogencarbonate; In ethanol; water; at 20 ℃; pH=8 - 9; Cooling with ice;

With hydrogenchloride; In water; pH=3 - 4;

Reference yield: 39.8%

: 109688-65-5
5-methyl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-2,4-dihydropyrazol-3-one

: 5-(3-amino-2-hydroxyphenyl)furan-2-carboxylic acid hydrobromide

: 1257792-41-8
(Z)-5-(2-hydroxy-3-{2-[-3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-4(5H)-1H-pyrazol-4-ylidene]hydrazin-1-yl}phenyl)furan-2-carboxylic acid

Guidance literature:: 5-(3-amino-2-hydroxyphenyl)furan-2-carboxylic acid hydrobromide; With hydrogenchloride; sodium nitrite; In water; for 0.333333h; Cooling with ice;

5-methyl-2-(5,6,7,8-tetrahydronaphthalen-2-yl)-2,4-dihydropyrazol-3-one; With sodium hydrogencarbonate; In ethanol; water; at 20 ℃; pH=8 - 9;

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 1257792-41-8
(Z)-5-(2-hydroxy-3-{2-[-3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-4(5H)-1H-pyrazol-4-ylidene]hydrazin-1-yl}phenyl)furan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium nitrate; sulfuric acid / water / 2 h / 20 - 25 °C

2.1: potassium carbonate / acetone / 40 h / 70 °C

3.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / etheroxalic acid dimethyl ether / 17 h / Reflux

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / Reflux

4.2: pH 3

5.1: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 3.5 h / Reflux

6.1: boron tribromide / dichloromethane / 1 h / 20 °C

6.2: 1 h

7.1: hydrogenchloride; sodium nitrite / water / 0.33 h / Cooling with ice

7.2: 20 °C / pH 8 - 9 / Cooling with ice

7.3: pH 3 - 4

With hydrogenchloride; sodium nitrate; sulfuric acid; ammonium formate; potassium acetate; boron tribromide; sodium carbonate; potassium carbonate; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; etheroxalic acid dimethyl ether; water; ethyl acetate; acetone;