(2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid allyl ester

Base Information

Chemical Name:(2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid allyl ester
CAS No.:135875-41-1
Molecular Formula:C₂₄H₂₃NO₅
Molecular Weight:405.45
Hs Code.:

Synonyms:(2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid allyl ester

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Chemical Property of (2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid allyl ester

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Technology Process of (2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid allyl ester

There total 1 articles about (2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 78-85-3,25120-30-3
2-methylpropenal

: 135875-40-0
3-(((allyloxy)carbonyl)methyl)-4,5-diphenyl-1-oxazolin-2-one

: 135875-41-1
(2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid allyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1016/S0040-4039(00)92692-3

Reference yield: 65.0%

: 135875-41-1
(2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid allyl ester

: 135875-42-2
(2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-benzyloxyamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)92692-3

Reference yield:

: 135875-41-1
(2S,3S)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoic acid allyl ester

: 135875-45-5,135969-38-9
(S)-[(2R,3S)-2-Isopropenyl-4-oxo-3-(2-oxo-4,5-diphenyl-oxazol-3-yl)-azetidin-1-yl]-phenyl-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / H₂NOBn, Pd(PPh₃)4 / CH₂Cl₂

2: 70 percent / dicyclohexylcarbodiimide, N-hydroxybenzotriazole / CH₂Cl₂

3: 50 percent / PPh₃, di-tert-butylazodicarboxylate / tetrahydrofuran

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-benzyloxyamine; di-tert-butyl-diazodicarboxylate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)92692-3