(E,E)-1'-(2-ethylhexyloxy)-5'-(2''-(2-ethylhexyloxy)-5''-methoxystyryl)-4'-methoxy-2'-(4-methylstyryl)benzene

Base Information

• Chemical Name: (E,E)-1'-(2-ethylhexyloxy)-5'-(2''-(2-ethylhexyloxy)-5''-methoxystyryl)-4'-methoxy-2'-(4-methylstyryl)benzene
• CAS No.: 1293393-83-5
• Molecular Formula: C₄₁H₅₆O₄
• Molecular Weight: 612.893
• Mol file: 1293393-83-5.mol

Synonyms:(E,E)-1'-(2-ethylhexyloxy)-5'-(2''-(2-ethylhexyloxy)-5''-methoxystyryl)-4'-methoxy-2'-(4-methylstyryl)benzene

Chemical Property of (E,E)-1'-(2-ethylhexyloxy)-5'-(2''-(2-ethylhexyloxy)-5''-methoxystyryl)-4'-methoxy-2'-(4-methylstyryl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E,E)-1'-(2-ethylhexyloxy)-5'-(2''-(2-ethylhexyloxy)-5''-methoxystyryl)-4'-methoxy-2'-(4-methylstyryl)benzene

There total 9 articles about (E,E)-1'-(2-ethylhexyloxy)-5'-(2''-(2-ethylhexyloxy)-5''-methoxystyryl)-4'-methoxy-2'-(4-methylstyryl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(E)-2-(2-ethylhexyloxy)-4-(2'-(2-ethylhexyloxy)-5'-methoxystyryl)-5-methoxybenzaldehyde (1293393-82-4) + diisopropyl 4-methylbenzyl phosphonate → (E,E)-1'-(2-ethylhexyloxy)-5'-(2''-(2-ethylhexyloxy)-5''-methoxystyryl)-4'-methoxy-2'-(4-methylstyryl)benzene (1293393-83-5)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

DOI:10.1021/jo200336m

Reference yield:

2-bromo-1-(2-ethylhexyloxy)-4-methoxybenzene (1293393-77-7) → (E,E)-1'-(2-ethylhexyloxy)-5'-(2''-(2-ethylhexyloxy)-5''-methoxystyryl)-4'-methoxy-2'-(4-methylstyryl)benzene (1293393-83-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride; acetic acid / water / 48 h / 80 °C

2.1: 16 h / Reflux

3.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 - 20 °C

4.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

4.2: 1 h / -78 - 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 24 h / 0 - 20 °C

With hydrogenchloride; n-butyllithium; potassium tert-butylate; acetic acid; In tetrahydrofuran; water; 3.1: Horner-Wadsworth-Emmons olefination / 5.1: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/jo200336m

Reference yield:

2-bromo-4-methoxyphenol (17332-11-5) → (E,E)-1'-(2-ethylhexyloxy)-5'-(2''-(2-ethylhexyloxy)-5''-methoxystyryl)-4'-methoxy-2'-(4-methylstyryl)benzene (1293393-83-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium hydroxide / acetone / 47 h / Reflux

2.1: hydrogenchloride; acetic acid / water / 48 h / 80 °C

3.1: 16 h / Reflux

4.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / 0 - 20 °C

5.1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

5.2: 1 h / -78 - 20 °C

6.1: potassium tert-butylate / tetrahydrofuran / 24 h / 0 - 20 °C

With hydrogenchloride; n-butyllithium; potassium tert-butylate; acetic acid; potassium hydroxide; In tetrahydrofuran; water; acetone; 4.1: Horner-Wadsworth-Emmons olefination / 6.1: Horner-Wadsworth-Emmons olefination;

DOI:10.1021/jo200336m

upstream raw materials:

(E)-1-bromo-2-(2-ethylhexyloxy)-4-(2'-(2-ethylhexyloxy)-5'-methoxystyryl)-5-methoxybenzene

2-(2-ethylhexyloxy)-5-methoxybenzaldehyde

(E)-2-(2-ethylhexyloxy)-4-(2'-(2-ethylhexyloxy)-5'-methoxystyryl)-5-methoxybenzaldehyde

C₁₆H₂₄BrClO₂