2-Bromo-4-methoxyphenol

Base Information

• Chemical Name: 2-Bromo-4-methoxyphenol
• CAS No.: 17332-11-5
• Molecular Formula: C7H7BrO2
• Molecular Weight: 203.035
• Hs Code.: 29071990
• NSC Number: 168509
• DSSTox Substance ID: DTXSID70304961
• Nikkaji Number: J307.702K
• Wikidata: Q72446065
• Mol file: 17332-11-5.mol

Synonyms:2-Bromo-4-methoxyphenol;17332-11-5;2-Bromo-4-methoxybenzenol;Phenol, 2-bromo-4-methoxy-;3-Bromo-4-hydroxyanisole;2-Bromo-4-methoxy-phenol;MFCD02113712;5-Bromo-2-methoxyphenol;4-Bromo-2-hydroxyanisole;NSC168509;2-bromo4methoxyphenol;2-bromo-4methoxyphenol;2-bromo4-methoxyphenol;2-brom-4-methoxyphenol;O(C)c1ccc(O)c(Br)c1;SCHEMBL320713;DTXSID70304961;AKOS005070745;AB10935;AC-3767;AM61797;CS-W000055;NSC 168509;NSC-168509;SY018293;B3135;FT-0637534;A19853;A19896;EN300-103076;5Y-0804;4-Methoxy-2-bromophenol;J-508307;J-511934

Chemical Property of 2-Bromo-4-methoxyphenol

Chemical Property:

• Vapor Pressure: 0.0183mmHg at 25°C
• Melting Point: 47 °C
• Refractive Index: 1.578
• Boiling Point: 245.5 °C at 760 mmHg
• PKA: 8.92±0.18(Predicted)
• Flash Point: 102.2 °C
• PSA: 29.46000
• Density: 1.585 g/cm³
• LogP: 2.16330
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 201.96294
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-4-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)O)Br

Technology Process of 2-Bromo-4-methoxyphenol

There total 11 articles about 2-Bromo-4-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-phenol (150-76-5) → 2-bromo-4-methoxyphenol (17332-11-5)

Guidance literature:

With bromine; In dichloromethane;

DOI:10.1021/ol035822q

Reference yield: 88.0%

(4-methoxyphenoxy)trimethylsilane (6689-38-9) → 2-bromo-4-methoxyphenol (17332-11-5)

Guidance literature:

With tris(2,2'-bipyridyl)ruthenium dichloride; carbon tetrabromide; In acetonitrile; at 20 ℃; Solvent; Irradiation;

DOI:10.3762/bjoc.10.53

Reference yield: 85.0%

4-(tert-butyldimethylsilyloxy)anisole (62790-87-8) → 2-bromo-4-methoxyphenol (17332-11-5)

Guidance literature:

With tris(2,2'-bipyridyl)ruthenium dichloride; carbon tetrabromide; In acetonitrile; at 20 ℃; Irradiation;

DOI:10.3762/bjoc.10.53

upstream raw materials:

4-methoxy-phenol

methanol

3-[(trimethylsilyl)oxy]cyclohex-2-en-1-one

2-bromo-4,4-dimethoxycyclohexa-2,5-dienone

Downstream raw materials:

2-bromo-4,4-dimethoxycyclohexa-2,5-dienone

4-[6-(2-Bromo-4-methoxyphenoxy)hexyl]-3,5-heptanedione

2-(o-Brom-p-methoxyphenoxy)-tetrahydropyran

2-(1-Hydroxy-1,3-dimethyl-but-2-enyl)-4-methoxy-phenol