[2-(allyloxy)-4-methoxyphenyl][2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone

Base Information

Chemical Name:[2-(allyloxy)-4-methoxyphenyl][2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone
CAS No.:668455-71-8
Molecular Formula:C₂₁H₁₈F₃NO₄
Molecular Weight:405.373
Hs Code.:

Synonyms:[2-(allyloxy)-4-methoxyphenyl][2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone

Suppliers and Price of [2-(allyloxy)-4-methoxyphenyl][2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-(allyloxy)-4-methoxyphenyl][2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone

Chemical Property:

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Technology Process of [2-(allyloxy)-4-methoxyphenyl][2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone

There total 4 articles about [2-(allyloxy)-4-methoxyphenyl][2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87359-53-3
2-allyloxy-4-methoxy benzoyl chloride

: 668455-71-8
[2-(allyloxy)-4-methoxyphenyl][2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone

Guidance literature:: 2-methyl-6-(trifluoromethoxy)-1H-indole; With ethylmagnesium bromide; zinc(II) chloride; In dichloromethane; at 20 ℃;

2-allyloxy-4-methoxy benzoyl chloride; In dichloromethane; for 1h;

Reference yield:

: C₁₁H₁₁ClO₄

: 57330-49-1
2-methyl-6-(trifluoromethoxy)-1H-indole

: 668455-71-8
[2-(allyloxy)-4-methoxyphenyl][2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone

Guidance literature:: 2-methyl-6-(trifluoromethoxy)-1H-indole; With ethylmagnesium bromide; zinc(II) chloride; In diethyl ether; dichloromethane; at 20 ℃; for 1h;

C₁₁H₁₁ClO₄; In diethyl ether; dichloromethane; for 1h;

With ammonium chloride; In diethyl ether; dichloromethane; water;

Reference yield:

: 1535-73-5
m-trifluoromethoxyaniline

: 668455-71-8
[2-(allyloxy)-4-methoxyphenyl][2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-butyl hypochlorite; triethylamine / 0 °C

1.2: 60 percent / Raney-Ni / ethanol

2.1: ZnCl₂; EtMgBr / tetrahydrofuran

2.2: tetrahydrofuran

With tert-butylhypochlorite; ethylmagnesium bromide; triethylamine; zinc(II) chloride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.03.092