1H-Indole, 2-methyl-6-(trifluoromethoxy)-

Base Information

• Chemical Name: 1H-Indole, 2-methyl-6-(trifluoromethoxy)-
• CAS No.: 57330-49-1
• Molecular Formula: C10H8F3NO
• Molecular Weight: 215.175
• Mol file: 57330-49-1.mol

Synonyms:2-METHYL-6-TRIFLUOROMETHOXY-1H-INDOLE;2-methyl-6-trifluoromethoxyindole;2-Methyl-6-trifluormethoxy-indol;

Chemical Property of 1H-Indole, 2-methyl-6-(trifluoromethoxy)-

Chemical Property:

• Vapor Pressure: 0.0166mmHg at 25°C
• Boiling Point: 263.6oC at 760 mmHg
• Flash Point: 113.2oC
• PSA: 25.02000
• Density: 1.357g/cm3
• LogP: 3.37490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Methyl-6-(trifluoromethoxy)-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole, 2-methyl-6-(trifluoromethoxy)-

There total 9 articles about 1H-Indole, 2-methyl-6-(trifluoromethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-[2-nitro-4-(trifluoromethoxy)phenyl]acetone (57330-59-3) → 2-methyl-6-(trifluoromethoxy)-1H-indole (57330-49-1)

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrogen; at 0 - 60 ℃; for 7h; under 3102.97 Torr; Large scale reaction;

DOI:10.1021/op8002882

Reference yield: 84.0%

2-nitro-1-[(1E)-prop-1-en-1-yl]-4-(trifluoromethoxy)benzene → 2-methyl-6-(trifluoromethoxy)-1H-indole (57330-49-1)

Guidance literature:

With 3,4,7,8-Tetramethyl-o-phenanthrolin; carbon monoxide; palladium(II) trifluoroacetate; In N,N-dimethyl-formamide; at 80 ℃; for 16h; under 775.722 Torr;

DOI:10.1016/j.tet.2005.03.142

Reference yield: 74.0%

C12H7F6NO2 (1139688-65-5) → 2-methyl-6-(trifluoromethoxy)-1H-indole (57330-49-1)

Guidance literature:

With triethylamine;

DOI:10.1021/op8002882

upstream raw materials:

methylsulfanyl-acetone

m-trifluoromethoxyaniline

2-[[2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]thio]benzoic acid

C₁₂H₇F₆NO₂

Downstream raw materials:

[2-(allyloxy)-4-methoxyphenyl][2-methyl-6-(trifluoromethoxy)-1H-indol-3-yl]methanone

[3-(4-chloro-benzoyl)-2-methyl-6-trifluoromethoxy-indol-1-yl]-acetic acid methyl ester

[3-(4-chloro-benzoyl)-2-methyl-6-trifluoromethoxy-indol-1-yl]-acetic acid

C₂₈H₂₅ClF₃N₃O₃S

Refernces

• 1、 Liu, Weiguo,Liu, Kun,Wood, Harold B.,McCann, Margaret E.,Doebber, Thomas W.,Chang, Ching H.,Akiyama, Taro E.,Einstein, Monica,Berger, Joel P.,Meinke, Peter T.. "Discovery of a peroxisome proliferator activated receptor γ (PPARγ) modulator with balanced PPARα activity for the treatment of type 2 diabetes and dyslipidemia". experimental part. p. 4443 - 4453. Retrieved 2010/03/02.
• 2、 -. "NOVEL CRYSTALLINE FORMS OF ANTIDIABETIC COMPOUNDS". Page/Page column 23. . Retrieved 2010/11/23.