(5R,6S)-5-(3,4-dimethoxyphenyl)-2,2,3,3,9,9,10,10-octamethyl-N-[(R)-1-phenylethyl]-4,8-dioxa-3,9-disilaundcan-6-amine

Base Information

Chemical Name:(5R,6S)-5-(3,4-dimethoxyphenyl)-2,2,3,3,9,9,10,10-octamethyl-N-[(R)-1-phenylethyl]-4,8-dioxa-3,9-disilaundcan-6-amine
CAS No.:1354006-25-9
Molecular Formula:C₃₁H₅₃NO₄Si₂
Molecular Weight:559.937
Hs Code.:

Synonyms:(5R,6S)-5-(3,4-dimethoxyphenyl)-2,2,3,3,9,9,10,10-octamethyl-N-[(R)-1-phenylethyl]-4,8-dioxa-3,9-disilaundcan-6-amine

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Chemical Property of (5R,6S)-5-(3,4-dimethoxyphenyl)-2,2,3,3,9,9,10,10-octamethyl-N-[(R)-1-phenylethyl]-4,8-dioxa-3,9-disilaundcan-6-amine

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Technology Process of (5R,6S)-5-(3,4-dimethoxyphenyl)-2,2,3,3,9,9,10,10-octamethyl-N-[(R)-1-phenylethyl]-4,8-dioxa-3,9-disilaundcan-6-amine

There total 5 articles about (5R,6S)-5-(3,4-dimethoxyphenyl)-2,2,3,3,9,9,10,10-octamethyl-N-[(R)-1-phenylethyl]-4,8-dioxa-3,9-disilaundcan-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354006-46-4
C₁₉H₂₅NO₄

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1354006-25-9
(5R,6S)-5-(3,4-dimethoxyphenyl)-2,2,3,3,9,9,10,10-octamethyl-N-[(R)-1-phenylethyl]-4,8-dioxa-3,9-disilaundcan-6-amine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 20h; Reflux; Inert atmosphere;
DOI:10.1016/j.tet.2011.11.031

Reference yield:

: 1354006-20-4
(S)-(3,4-dimethoxyphenyl)[(R)-1-(1-phenylethyl)aziridin-2-yl]methanone

: 1354006-25-9
(5R,6S)-5-(3,4-dimethoxyphenyl)-2,2,3,3,9,9,10,10-octamethyl-N-[(R)-1-phenylethyl]-4,8-dioxa-3,9-disilaundcan-6-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc(II) chloride / methanol / 0.5 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 8 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

2.3: 20 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 20 h / 0 °C / Reflux; Inert atmosphere

With dmap; acetic acid; triethylamine; zinc(II) chloride; In methanol; dichloromethane;
DOI:10.1016/j.tet.2011.11.031

Reference yield:

: 1354006-22-6
(R)-(3,4-dimethoxyphenyl)[(S)-1-((R)-1-phenylethyl)aziridin-2-yl]methanol

: 1354006-25-9
(5R,6S)-5-(3,4-dimethoxyphenyl)-2,2,3,3,9,9,10,10-octamethyl-N-[(R)-1-phenylethyl]-4,8-dioxa-3,9-disilaundcan-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / dichloromethane / 8 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 20 h / 0 °C / Reflux; Inert atmosphere

With dmap; acetic acid; triethylamine; In dichloromethane;
DOI:10.1016/j.tet.2011.11.031