amino acetic acid (1S, 2R, 5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester hydrochloride

Base Information

• Chemical Name: amino acetic acid (1S, 2R, 5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester hydrochloride
• CAS No.: 130156-97-7
• Molecular Formula: C₁₈H₂₇NO₂*ClH
• Molecular Weight: 325.879
• Mol file: 130156-97-7.mol

Synonyms:amino acetic acid (1S, 2R, 5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester hydrochloride

Chemical Property of amino acetic acid (1S, 2R, 5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of amino acetic acid (1S, 2R, 5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester hydrochloride

There total 5 articles about amino acetic acid (1S, 2R, 5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(-)-8-phenylmenthyl glycinate (120130-28-1) → amino acetic acid (1S, 2R, 5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester hydrochloride (130156-97-7)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 2h;

DOI:10.1016/S0040-4039(00)94713-0

Reference yield:

(1S,2R,5S)-8-(+)-phenylmenthol (57707-91-2) → amino acetic acid (1S, 2R, 5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester hydrochloride (130156-97-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / N,N-diethylaniline / diethyl ether / Heating

2: 91 percent / NaN₃ / acetone; H₂O / Heating

3: 95 percent / hydrogen / Pd/BaSO₄ / methanol

4: 92 percent / HCl (gas) / diethyl ether / 2 h

With hydrogenchloride; sodium azide; hydrogen; N,N-diethylaniline; Pd-BaSO₄; In methanol; diethyl ether; water; acetone;

DOI:10.1016/S0040-4039(00)94713-0

Reference yield:

(-)-(1S,2R,5S)-1-Chloroacetoxy-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexane (122449-89-2) → amino acetic acid (1S, 2R, 5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester hydrochloride (130156-97-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / NaN₃ / acetone; H₂O / Heating

2: 95 percent / hydrogen / Pd/BaSO₄ / methanol

3: 92 percent / HCl (gas) / diethyl ether / 2 h

With hydrogenchloride; sodium azide; hydrogen; Pd-BaSO₄; In methanol; diethyl ether; water; acetone;

DOI:10.1016/S0040-4039(00)94713-0

upstream raw materials:

(-)-8-phenylmenthyl glycinate

(1S,2R,5S)-8-(+)-phenylmenthol

(-)-(1S,2R,5S)-1-Chloroacetoxy-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexane

Downstream raw materials:

(Benzhydrylidene-amino)-acetic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

(S)-2-(Benzhydrylidene-amino)-pent-4-enoic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

(R)-2-(Benzhydrylidene-amino)-pent-4-enoic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester