3-[4-(3-chlorophenyl)-2H-pyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine hydrochloride

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Chemical Name:3-[4-(3-chlorophenyl)-2H-pyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine hydrochloride
CAS No.:1385020-92-7
Molecular Formula:C₁₆H₁₁ClN₄*ClH
Molecular Weight:331.204
Hs Code.:

Synonyms:3-[4-(3-chlorophenyl)-2H-pyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine hydrochloride

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Chemical Property of 3-[4-(3-chlorophenyl)-2H-pyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine hydrochloride

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Technology Process of 3-[4-(3-chlorophenyl)-2H-pyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine hydrochloride

There total 4 articles about 3-[4-(3-chlorophenyl)-2H-pyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 5815-08-7
tert-Butoxybis(dimethylamino)methane

: 1385021-00-0
2-(3-chlorophenyl)-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone

: 1385020-92-7
3-[4-(3-chlorophenyl)-2H-pyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine hydrochloride

Guidance literature:: tert-Butoxybis(dimethylamino)methane; 2-(3-chlorophenyl)-1-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone; In N,N-dimethyl-formamide; for 16h;

With hydrazine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

With hydrazine hydrate; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 6h;

Reference yield:

: 156270-06-3
7-azaindolyl-3-carboxylic acid

: 1385020-92-7
3-[4-(3-chlorophenyl)-2H-pyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 0.25 h / 20 °C

1.2: 18.08 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice

2.2: 14 h / 20 °C

2.3: Cooling with ice

3.1: tetrahydrofuran / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 16 h

4.2: 0.25 h / 20 °C

4.3: 6 h / 20 - 80 °C

With 1-hydroxy-7-aza-benzotriazole; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1385020-98-3
N-methoxy-N-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

: 1385020-92-7
3-[4-(3-chlorophenyl)-2H-pyrazol-3-yl]-1H-pyrrolo[2,3-b]pyridine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice

1.2: 14 h / 20 °C

1.3: Cooling with ice

2.1: tetrahydrofuran / 0 - 20 °C

3.1: N,N-dimethyl-formamide / 16 h

3.2: 0.25 h / 20 °C

3.3: 6 h / 20 - 80 °C

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;