(R)-2-((S)-(3-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

Base Information

Chemical Name:(R)-2-((S)-(3-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid
CAS No.:1558057-47-8
Molecular Formula:C₁₉H₂₇FO₃Si
Molecular Weight:350.505
Hs Code.:

Synonyms:(R)-2-((S)-(3-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((S)-(3-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

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Technology Process of (R)-2-((S)-(3-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

There total 7 articles about (R)-2-((S)-(3-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1558057-44-5
(S)-4-benzyl-3-((R)-2-((S)-(3-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoyl)oxazolidin-2-one

: 1558057-47-8
(R)-2-((S)-(3-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

Guidance literature:: With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water; at 0 - 25 ℃; Inert atmosphere;
DOI:10.1021/jm4017224

Reference yield:

: C₁₁H₁₆O₃

: 1558057-47-8
(R)-2-((S)-(3-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: lithium chloride / tetrahydrofuran / 12 h / 25 °C / Inert atmosphere

2: triethylamine; magnesium chloride / ethyl acetate / 72 h / 25 °C / Inert atmosphere

3: trifluoroacetic acid / methanol / 1.5 h / Inert atmosphere

4: 2,6-dimethylpyridine; t-butyldimethylsiyl triflate / dichloromethane / 0 - 25 °C / Inert atmosphere

5: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere

With 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; dihydrogen peroxide; triethylamine; trifluoroacetic acid; lithium chloride; magnesium chloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; 2: |Aldol Condensation;
DOI:10.1021/jm4017224

Reference yield:

: C₂₆H₃₀FNO₄Si

: 1558057-47-8
(R)-2-((S)-(3-fluorophenyl)((trimethylsilyl)oxy)methyl)hex-5-ynoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / methanol / 1.5 h / Inert atmosphere

2: 2,6-dimethylpyridine; t-butyldimethylsiyl triflate / dichloromethane / 0 - 25 °C / Inert atmosphere

3: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere

With 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; dihydrogen peroxide; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm4017224