PChd-L-Ile-Leu-OH

Base Information

• Chemical Name: PChd-L-Ile-Leu-OH
• CAS No.: 82636-90-6
• Molecular Formula: C₃₂H₄₈N₂O₄
• Molecular Weight: 524.744
• Mol file: 82636-90-6.mol

Synonyms:PChd-L-Ile-Leu-OH

Chemical Property of PChd-L-Ile-Leu-OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of PChd-L-Ile-Leu-OH

There total 10 articles about PChd-L-Ile-Leu-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

PChd-L-Ile-Leu-OMe (82636-89-3) → PChd-L-Ile-Leu-OH (82636-90-6)

Guidance literature:

With sodium hydroxide; In methanol; at 40 ℃; for 2h;

DOI:10.1002/jlac.198219820608

Reference yield:

PChd-L-Ala-Gly-OH → PChd-L-Ile-Leu-OH (82636-90-6)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / Pd/10percent on charcoal / methanol / 3 h

2: 91 percent / 2,6-dimethylpyridine; tetraethylammonium tetrafluoroborate / CH₂Cl₂ / 8 h / anodic oxidation

3: 79 percent / 1 N NaOH / methanol / 4 h

4: 1.) N-methylmorpholin, 1-hydroxybenzotriazole; 2.) N,N'-dicyclohexylcarbodiimide / 1.) CH₂Cl₂; 2.) CH₂Cl₂, 1 h, 0 deg C; 24 h at room temp.

5: 89 percent / 2 N NaOH / methanol / 2 h / 40 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; sodium hydroxide; hydrogen; N,N,N,N-tetraethylammonium tetrafluoroborate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/jlac.198219820608

Reference yield:

PChd-L-Ala-OMe (82636-78-0) → PChd-L-Ile-Leu-OH (82636-90-6)

Guidance literature:

Multi-step reaction with 8 steps

1: 94 percent / 1 N NaOH / methanol / 4 h

2: 1.) N-methylmorpholin, 1-hydroxybenzotriazole; 2.) N,N'-dicyclohexylcarbodiimide / 1.) CH₂Cl₂; 2.) CH₂Cl₂, 1 h, 0 deg C; 24 h at room temp.

3: 1 N NaOH / methanol / 2 h / 40 °C

4: H₂ / Pd/10percent on charcoal / methanol / 3 h

5: 91 percent / 2,6-dimethylpyridine; tetraethylammonium tetrafluoroborate / CH₂Cl₂ / 8 h / anodic oxidation

6: 79 percent / 1 N NaOH / methanol / 4 h

7: 1.) N-methylmorpholin, 1-hydroxybenzotriazole; 2.) N,N'-dicyclohexylcarbodiimide / 1.) CH₂Cl₂; 2.) CH₂Cl₂, 1 h, 0 deg C; 24 h at room temp.

8: 89 percent / 2 N NaOH / methanol / 2 h / 40 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; sodium hydroxide; hydrogen; N,N,N,N-tetraethylammonium tetrafluoroborate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/jlac.198219820608

upstream raw materials:

PChd-L-Ile-Leu-OMe

L-isoleucine methyl ester

L-isoleucine ethyl ester

PChd-L-Ala-OMe

Downstream raw materials:

PChd-L-Ile-Leu-Leu-Ala-OMe

PChd-L-Pro-L-Leu-Gly-NH₂

PChd-L-Leu-OBzl

PChd-L-Leu-Gly-NH₂