2,6-anhydro-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-7-O-methyl-D-glycero-D-ido-heptonate

Base Information

Chemical Name:2,6-anhydro-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-7-O-methyl-D-glycero-D-ido-heptonate
CAS No.:338951-43-2
Molecular Formula:C₆₀H₁₀₀F₂NO₁₁P
Molecular Weight:1080.42
Hs Code.:

2,6-anhydro-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-7-O-methyl-D-glycero-D-ido-heptonate

Synonyms:2,6-anhydro-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-7-O-methyl-D-glycero-D-ido-heptonate

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Chemical Property of 2,6-anhydro-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-7-O-methyl-D-glycero-D-ido-heptonate

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Technology Process of 2,6-anhydro-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-7-O-methyl-D-glycero-D-ido-heptonate

There total 5 articles about 2,6-anhydro-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-7-O-methyl-D-glycero-D-ido-heptonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 338951-88-5
diphenylmethyl 2,6-anhydro-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-7-O-methyl-D-glycero-D-ido-heptonate

: 338951-43-2
2,6-anhydro-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-7-O-methyl-D-glycero-D-ido-heptonate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 2h;
DOI:10.1016/S0008-6215(01)00055-6

Reference yield:

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 338951-43-2
2,6-anhydro-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-7-O-methyl-D-glycero-D-ido-heptonate

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / DMAP / CH₂Cl₂ / 2 h / 20 °C

2: 88 percent / HCl; water / tetrahydrofuran / 6 h / 20 °C

3: 70 percent / 2,6-di-tert-butyl-4-methyl-pyridine / CH₂Cl₂ / 3 h / 20 °C

4: 69 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C

With hydrogenchloride; dmap; 2,6-di-tert-butyl-4-methylpyridine; water; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0008-6215(01)00055-6

Reference yield:

: 338951-86-3
diphenylmethyl 2,6-anhydro-7-O-tert-butyldimethylsilyl-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-D-glycero-D-ido-heptonate

: 338951-43-2
2,6-anhydro-3-deoxy-3-(2,2-difluorotetradecanamido)-5-O-diphenylphosphono-4-O-[(R)-3-(dodecyloxy)tetradecyl]-7-O-methyl-D-glycero-D-ido-heptonate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / HCl; water / tetrahydrofuran / 6 h / 20 °C

2: 70 percent / 2,6-di-tert-butyl-4-methyl-pyridine / CH₂Cl₂ / 3 h / 20 °C

3: 69 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C

With hydrogenchloride; 2,6-di-tert-butyl-4-methylpyridine; water; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0008-6215(01)00055-6