methyl 2-[[[2-butyl-1-[4-(carboxyphenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate

Base Information

• Chemical Name: methyl 2-[[[2-butyl-1-[4-(carboxyphenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate
• CAS No.: 155741-86-9
• Molecular Formula: C₂₄H₂₇N₃O₄
• Molecular Weight: 421.496

Synonyms:methyl 2-[[[2-butyl-1-[4-(carboxyphenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate

Chemical Property of methyl 2-[[[2-butyl-1-[4-(carboxyphenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate

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Technology Process of methyl 2-[[[2-butyl-1-[4-(carboxyphenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate

There total 3 articles about methyl 2-[[[2-butyl-1-[4-(carboxyphenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

methyl 2-[[[2-butyl-1-[[4-(methoxycarbonyl)phenyl]methyl]-1H-imidazol-5-yl]methyl]amino]benzoate (155740-67-3) → methyl 2-[[[2-butyl-1-[4-(carboxyphenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate (155741-86-9)

Guidance literature:

With sodium hydroxide; In methanol; at 50 ℃; for 3.5h;

DOI:10.1021/jm991050l

Reference yield:

2-carbomethoxyaniline (134-20-3) → methyl 2-[[[2-butyl-1-[4-(carboxyphenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate (155741-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 2,6-dimethylpyridine / toluene / 8 h / Heating

2: 55 percent / aq. NaOH / methanol / 3.5 h / 50 °C

With 2,6-dimethylpyridine; sodium hydroxide; In methanol; toluene; 1: Alkylation / 2: Hydrolysis;

DOI:10.1021/jm991050l

Reference yield:

2-butyl-1-<(4-carbomethoxyphenyl)methyl>-5-(chloromethyl)imidazole hydrochloride → methyl 2-[[[2-butyl-1-[4-(carboxyphenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate (155741-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 2,6-dimethylpyridine / toluene / 8 h / Heating

2: 55 percent / aq. NaOH / methanol / 3.5 h / 50 °C

With 2,6-dimethylpyridine; sodium hydroxide; In methanol; toluene; 1: Alkylation / 2: Hydrolysis;

DOI:10.1021/jm991050l

upstream raw materials:

methyl 2-[[[2-butyl-1-[[4-(methoxycarbonyl)phenyl]methyl]-1H-imidazol-5-yl]methyl]amino]benzoate

2-carbomethoxyaniline

Downstream raw materials:

methyl 2-[[[2-butyl-1-[(4-((((2-chlorophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate

methyl 2-[[[2-butyl-1-[(4-((((2-azidophenyl)sulfonyl)amino)carbonyl)phenyl)methyl]-1H-imidazol-5-yl]methyl]amino]benzoate

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