(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-(R)-methylmethanol

Base Information

Chemical Name:(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-(R)-methylmethanol
CAS No.:234452-01-8
Molecular Formula:C₁₆H₂₃NO
Molecular Weight:245.365
Hs Code.:

Synonyms:(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-(R)-methylmethanol

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Chemical Property of (1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-(R)-methylmethanol

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Technology Process of (1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-(R)-methylmethanol

There total 5 articles about (1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-(R)-methylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 234451-99-1
(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-methylketone

: 234452-01-8
(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-(R)-methylmethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃; for 1.5h;
DOI:10.1002/(SICI)1521-3765(19990604)5:6<1692::AID-CHEM1692>3.0.CO;2-M

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 234452-01-8
(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-(R)-methylmethanol

Guidance literature:: Multi-step reaction with 4 steps

1: HCl / H₂O / 0.5 h / 0 °C

2: HCl / CH₂Cl₂ / -78 - 20 °C

3: 95 percent / H₂; K₂CO₃ / 10 percent Pd/C / methanol / 3 h / 20 °C

4: 61 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / -78 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; 1: Condensation / 2: Cycloaddition / 3: Catalytic hydrogenation / 4: Reduction;
DOI:10.1002/(SICI)1521-3765(19990604)5:6<1692::AID-CHEM1692>3.0.CO;2-M

Reference yield:

: 542-92-7,25568-84-7,7313-32-8
cyclopenta-1,3-diene

: 234452-01-8
(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-(R)-methylmethanol

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / CH₂Cl₂ / -78 - 20 °C

2: 95 percent / H₂; K₂CO₃ / 10 percent Pd/C / methanol / 3 h / 20 °C

3: 61 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / -78 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 1: Cycloaddition / 2: Catalytic hydrogenation / 3: Reduction;
DOI:10.1002/(SICI)1521-3765(19990604)5:6<1692::AID-CHEM1692>3.0.CO;2-M