(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-methylketone

Base Information

Chemical Name:(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-methylketone
CAS No.:234451-99-1
Molecular Formula:C₁₆H₂₁NO
Molecular Weight:243.349
Hs Code.:

Synonyms:(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-methylketone

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Chemical Property of (1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-methylketone

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Technology Process of (1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-methylketone

There total 4 articles about (1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-methylketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 234451-97-9
(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]hept-5-ene-3-methylketone

: 234451-99-1
(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-methylketone

Guidance literature:: With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; at 20 ℃; for 3h;
DOI:10.1002/(SICI)1521-3765(19990604)5:6<1692::AID-CHEM1692>3.0.CO;2-M

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 234451-99-1
(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-methylketone

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / H₂O / 0.5 h / 0 °C

2: HCl / CH₂Cl₂ / -78 - 20 °C

3: 95 percent / H₂; K₂CO₃ / 10 percent Pd/C / methanol / 3 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; water; 1: Condensation / 2: Cycloaddition / 3: Catalytic hydrogenation;
DOI:10.1002/(SICI)1521-3765(19990604)5:6<1692::AID-CHEM1692>3.0.CO;2-M

Reference yield:

: 542-92-7,25568-84-7,7313-32-8
cyclopenta-1,3-diene

: 234451-99-1
(1S,3R,4R)-2-[(S)-1-Phenylethylamino]-2-azabicyclo[2.2.1]heptane-3-methylketone

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / CH₂Cl₂ / -78 - 20 °C

2: 95 percent / H₂; K₂CO₃ / 10 percent Pd/C / methanol / 3 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; dichloromethane; 1: Cycloaddition / 2: Catalytic hydrogenation;
DOI:10.1002/(SICI)1521-3765(19990604)5:6<1692::AID-CHEM1692>3.0.CO;2-M