N-allyl-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide

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Chemical Name:N-allyl-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide
CAS No.:1592907-59-9
Molecular Formula:C₂₆H₃₂N₂O₇
Molecular Weight:484.549
Hs Code.:

Synonyms:N-allyl-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide

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Chemical Property of N-allyl-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide

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Technology Process of N-allyl-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide

There total 2 articles about N-allyl-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 958138-35-7
C₁₅H₂₁NO₆

: 1592907-59-9
N-allyl-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 1 h / 20 °C / Inert atmosphere

2: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

With lithium borohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; acetonitrile;
DOI:10.1002/ejoc.201301769

Reference yield:

: 1592907-28-2
C₁₃H₁₅NO₃

: 1592907-59-9
N-allyl-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 1 h / 20 °C / Inert atmosphere

2: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

With lithium borohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; acetonitrile;
DOI:10.1002/ejoc.201301769

Reference yield: 87.0%

: 1592907-59-9
N-allyl-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide

: 106-95-6
allyl bromide

: 1592907-74-8
N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide

Guidance literature:: N-allyl-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Inert atmosphere;

allyl bromide; In tetrahydrofuran; at 0 ℃; for 6h; Inert atmosphere;
DOI:10.1002/ejoc.201301769