(3S,10aS,15bS,E)-4-benzoyl-13-((2-methoxyethoxy)methoxy)-3-methyl-4,5,8,10,10a,15b-hexahydro-1H-benzofuro[2,3-c][1,5,8]oxadiazacyclododecin-2(3H)-one

Base Information

Chemical Name:(3S,10aS,15bS,E)-4-benzoyl-13-((2-methoxyethoxy)methoxy)-3-methyl-4,5,8,10,10a,15b-hexahydro-1H-benzofuro[2,3-c][1,5,8]oxadiazacyclododecin-2(3H)-one
CAS No.:1592907-89-5
Molecular Formula:C₂₇H₃₂N₂O₇
Molecular Weight:496.56
Hs Code.:

Synonyms:(3S,10aS,15bS,E)-4-benzoyl-13-((2-methoxyethoxy)methoxy)-3-methyl-4,5,8,10,10a,15b-hexahydro-1H-benzofuro[2,3-c][1,5,8]oxadiazacyclododecin-2(3H)-one

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Chemical Property of (3S,10aS,15bS,E)-4-benzoyl-13-((2-methoxyethoxy)methoxy)-3-methyl-4,5,8,10,10a,15b-hexahydro-1H-benzofuro[2,3-c][1,5,8]oxadiazacyclododecin-2(3H)-one

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Technology Process of (3S,10aS,15bS,E)-4-benzoyl-13-((2-methoxyethoxy)methoxy)-3-methyl-4,5,8,10,10a,15b-hexahydro-1H-benzofuro[2,3-c][1,5,8]oxadiazacyclododecin-2(3H)-one

There total 5 articles about (3S,10aS,15bS,E)-4-benzoyl-13-((2-methoxyethoxy)methoxy)-3-methyl-4,5,8,10,10a,15b-hexahydro-1H-benzofuro[2,3-c][1,5,8]oxadiazacyclododecin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1592907-74-8
N-allyl-N-((S)-1-((2S,3S)-2-(allyloxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide

: 1592907-89-5
(3S,10aS,15bS,E)-4-benzoyl-13-((2-methoxyethoxy)methoxy)-3-methyl-4,5,8,10,10a,15b-hexahydro-1H-benzofuro[2,3-c][1,5,8]oxadiazacyclododecin-2(3H)-one

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere; Reflux;
DOI:10.1002/ejoc.201301769

Reference yield:

: 1592907-59-9
N-allyl-N-((S)-1-((2S,3S)-2-(hydroxymethyl)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-3-ylamino)-1-oxopropan-2-yl)benzamide

: 1592907-89-5
(3S,10aS,15bS,E)-4-benzoyl-13-((2-methoxyethoxy)methoxy)-3-methyl-4,5,8,10,10a,15b-hexahydro-1H-benzofuro[2,3-c][1,5,8]oxadiazacyclododecin-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

1.2: 6 h / 0 °C / Inert atmosphere

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 12 h / 20 °C / Inert atmosphere; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201301769

Reference yield:

: 1592907-44-2
(2S,3S)-ethyl 3-((S)-2-(N-allylbenzamido)propanamido)-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzo furan-2-carboxylate

: 1592907-89-5
(3S,10aS,15bS,E)-4-benzoyl-13-((2-methoxyethoxy)methoxy)-3-methyl-4,5,8,10,10a,15b-hexahydro-1H-benzofuro[2,3-c][1,5,8]oxadiazacyclododecin-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

2.2: 6 h / 0 °C / Inert atmosphere

3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 12 h / 20 °C / Inert atmosphere; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; lithium borohydride; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201301769