(1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane

Base Information

• Chemical Name: (1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane
• CAS No.: 274680-37-4
• Molecular Formula: C₁₆H₁₈N₄
• Molecular Weight: 266.346
• Mol file: 274680-37-4.mol

Synonyms:(1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane

Chemical Property of (1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane

There total 8 articles about (1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (1S,4S)-tert-butyl 5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (274681-10-6) → (1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane (274680-37-4)

Guidance literature:

formaldehyd; (1S,4S)-tert-butyl 5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate; With formic acid; water; at 100 ℃; for 1h;

With ammonia; In methanol; dichloromethane; water;

Reference yield: 96.0%

(1S,4S)-tert-butyl 5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (274681-10-6) → (1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane (274680-37-4)

Guidance literature:

With formaldehyd; In formic acid; at 100 ℃; for 1h;

Reference yield: 90.0%

(1S)-2-(6-phenyl-3-pyridazinyl)-2,5-diazabicyclo[2.2.1]heptane + formaldehyd (50-00-0,30525-89-4,61233-19-0) → (1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane (274680-37-4)

Guidance literature:

With sodium tris(acetoxy)borohydride; In acetonitrile; at 20 ℃; for 10h;

DOI:10.1016/j.bmcl.2010.04.105

upstream raw materials:

(1S,4S)-tert-butyl 5-(6-phenylpyridazin-3-yl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

formaldehyd

potassium hydroxide

(1S,4S)-2-(6-chloro-3-pyridazinyl)-5-methyl-2,5-diazabicyclo[2.2.1]heptane

Downstream raw materials:

[3H]-A-585539

A-585539

(S,S)-2-methyl-2-⁽³⁾H-methyl-5-(6-phenyl-pyridazin-3-yl)-5-aza-2-azonia-bicyclo[2.2.1]heptane iodide