tert-butyl 4-(4-(spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-ylamino)phenyl)-piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-ylamino)phenyl)-piperazine-1-carboxylate
CAS No.:1190962-22-1
Molecular Formula:C₃₁H₃₇N₅O₃
Molecular Weight:527.666
Hs Code.:

Synonyms:tert-butyl 4-(4-(spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-ylamino)phenyl)-piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-ylamino)phenyl)-piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-ylamino)phenyl)-piperazine-1-carboxylate

There total 8 articles about tert-butyl 4-(4-(spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-ylamino)phenyl)-piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1190961-30-8
spiro(chromeno(3,4-d)pyrimidine-5,1'-cyclohexane)-3-amine

: 352437-09-3
tert-butyl 4-(4-bromophenyl)piperazine-1-carboxylate

: 1190962-22-1
tert-butyl 4-(4-(spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-ylamino)phenyl)-piperazine-1-carboxylate

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; Reflux; Inert atmosphere;

Reference yield:

: 62756-20-1
spiro[chromene-2,1'-cyclohexan]-4(3H)-one

: 1190962-22-1
tert-butyl 4-(4-(spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-ylamino)phenyl)-piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / ethanol / 20 °C / Reflux; oil bath

1.2: Cooling with ice; Saturated solution

2.1: hydrogenchloride; water / 12 h / Heating; Reflux

3.1: pyridine; dihydrogen peroxide; methyltrioxorhenium(VII) / dichloromethane; water / 0 - 20 °C / Inert atmosphere; Cooling with ice

3.2: 20 °C / Inert atmosphere

4.1: boron trifluoride diethyl etherate / benzene / 2 h / 20 °C / Inert atmosphere

5.1: 1.33 h / Reflux

5.2: 80 °C

6.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Reflux; Inert atmosphere

With pyridine; hydrogenchloride; sodium tetrahydroborate; boron trifluoride diethyl etherate; water; dihydrogen peroxide; methyltrioxorhenium(VII); sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; dichloromethane; water; benzene;

Reference yield:

: 1190962-21-0
spiro[4H-chromene-2,1'-cyclohexan]-3-one

: 1190962-22-1
tert-butyl 4-(4-(spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-ylamino)phenyl)-piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1.33 h / Reflux

1.2: 80 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Reflux; Inert atmosphere

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane;