N-(4-(1-piperazinyl)phenyl)-spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-amine

Base Information

Chemical Name:N-(4-(1-piperazinyl)phenyl)-spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-amine
CAS No.:1190961-31-9
Molecular Formula:C₂₆H₂₉N₅O
Molecular Weight:427.549
Hs Code.:

Synonyms:N-(4-(1-piperazinyl)phenyl)-spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-amine

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Chemical Property of N-(4-(1-piperazinyl)phenyl)-spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-amine

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Technology Process of N-(4-(1-piperazinyl)phenyl)-spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-amine

There total 9 articles about N-(4-(1-piperazinyl)phenyl)-spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1190962-22-1
tert-butyl 4-(4-(spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-ylamino)phenyl)-piperazine-1-carboxylate

: 1190961-31-9
N-(4-(1-piperazinyl)phenyl)-spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 62756-20-1
spiro[chromene-2,1'-cyclohexan]-4(3H)-one

: 1190961-31-9
N-(4-(1-piperazinyl)phenyl)-spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / ethanol / 20 °C / Reflux; oil bath

1.2: Cooling with ice; Saturated solution

2.1: hydrogenchloride; water / 12 h / Heating; Reflux

3.1: pyridine; dihydrogen peroxide; methyltrioxorhenium(VII) / dichloromethane; water / 0 - 20 °C / Inert atmosphere; Cooling with ice

3.2: 20 °C / Inert atmosphere

4.1: boron trifluoride diethyl etherate / benzene / 2 h / 20 °C / Inert atmosphere

5.1: 1.33 h / Reflux

5.2: 80 °C

6.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Reflux; Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; boron trifluoride diethyl etherate; water; dihydrogen peroxide; methyltrioxorhenium(VII); trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; dichloromethane; water; benzene;

Reference yield:

: 1190962-21-0
spiro[4H-chromene-2,1'-cyclohexan]-3-one

: 1190961-31-9
N-(4-(1-piperazinyl)phenyl)-spiro[chromeno[3,4-d]pyrimidine-5,1'-cyclohexane]-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1.33 h / Reflux

1.2: 80 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Reflux; Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 20 °C

With trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;