2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxamide

Base Information

Chemical Name:2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxamide
CAS No.:114799-17-6
Molecular Formula:C₂₂H₂₂ClN₃O₃
Molecular Weight:411.888
Hs Code.:

Synonyms:2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxamide

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Chemical Property of 2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxamide

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Technology Process of 2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxamide

There total 14 articles about 2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 114798-30-0
2-Butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]imidazole-5-carboxaldehyde

: 114799-17-6
2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxamide

Guidance literature:: With sodium cyanide; manganese(IV) oxide; ammonia; In isopropyl alcohol; at 25 ℃; for 65h;
DOI:10.1021/jm00112a031

Reference yield:

: isopropyl alcohol chloroform

: 114798-30-0
2-Butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]imidazole-5-carboxaldehyde

: 67-63-0,8013-70-5
isopropyl alcohol

: 114799-17-6
2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxamide

Guidance literature:: With manganese dioxide; In water;

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 114799-17-6
2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

6: 81 percent / 10percent aq. NaOH / ethanol / 14 h / Heating

7: 49 percent / manganese dioxide / tetrahydrofuran / 120 h / 25 °C

8: 26 percent / ammonia, sodium cyanide, manganese dioxide / propan-2-ol / 65 h / 25 °C

With hydrogenchloride; sodium cyanide; manganese(IV) oxide; sodium hydroxide; N-Bromosuccinimide; ammonia; sodium methylate; acetyl chloride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; isopropyl alcohol;
DOI:10.1021/jm00112a031