2-Butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]imidazole-5-carboxaldehyde

Base Information

Chemical Name:2-Butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]imidazole-5-carboxaldehyde
CAS No.:114798-30-0
Molecular Formula:C₂₂H₂₁ClN₂O₃
Molecular Weight:396.873
Hs Code.:

Synonyms:2-Butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]imidazole-5-carboxaldehyde

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Chemical Property of 2-Butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]imidazole-5-carboxaldehyde

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Technology Process of 2-Butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]imidazole-5-carboxaldehyde

There total 14 articles about 2-Butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]imidazole-5-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 114798-27-5
2-butyl-4-chloro-5-hydroxymethyl-1-[(2'carboxybiphenyl-4-yl)methyl]imidazole

: 114798-30-0
2-Butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]imidazole-5-carboxaldehyde

Guidance literature:: With manganese(IV) oxide; In tetrahydrofuran; at 25 ℃; for 120h;
DOI:10.1021/jm00112a031

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 114798-30-0
2-Butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]imidazole-5-carboxaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h

4: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

6: 81 percent / 10percent aq. NaOH / ethanol / 14 h / Heating

7: 49 percent / manganese dioxide / tetrahydrofuran / 120 h / 25 °C

With hydrogenchloride; manganese(IV) oxide; sodium hydroxide; N-Bromosuccinimide; sodium methylate; acetyl chloride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol;
DOI:10.1021/jm00112a031

Reference yield:

: 624-31-7
4-tolyl iodide

: 114798-30-0
2-Butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]imidazole-5-carboxaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 11 percent / Cu / 1 h / 210 °C

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

4: 81 percent / 10percent aq. NaOH / ethanol / 14 h / Heating

5: 49 percent / manganese dioxide / tetrahydrofuran / 120 h / 25 °C

With manganese(IV) oxide; sodium hydroxide; N-Bromosuccinimide; sodium methylate; copper; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol;
DOI:10.1021/jm00112a031