(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o,p-dibenzyloxyphenoxy)ethyl mesylate

Base Information

Chemical Name:(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o,p-dibenzyloxyphenoxy)ethyl mesylate
CAS No.:1338384-82-9
Molecular Formula:C₃₂H₃₉NO₈S
Molecular Weight:597.73
Hs Code.:

Synonyms:(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o,p-dibenzyloxyphenoxy)ethyl mesylate

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Chemical Property of (1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o,p-dibenzyloxyphenoxy)ethyl mesylate

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Technology Process of (1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o,p-dibenzyloxyphenoxy)ethyl mesylate

There total 4 articles about (1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o,p-dibenzyloxyphenoxy)ethyl mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1338384-61-4
(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o,p-dibenzyloxyphenoxy)ethanol

: 124-63-0
methanesulfonyl chloride

: 1338384-82-9
(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o,p-dibenzyloxyphenoxy)ethyl mesylate

Guidance literature:: With trialkyl amine; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/jm200937t

Reference yield:

: 152665-75-3
(S)-2-(2-bromoacetyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1338384-82-9
(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o,p-dibenzyloxyphenoxy)ethyl mesylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetone / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran / 20 °C

3: trialkyl amine / dichloromethane / 5 h / 20 °C

With sodium tetrahydroborate; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jm200937t

Reference yield:

: C₂₀H₁₇O₃^(1-)*Na⁽¹⁺⁾

: 1338384-82-9
(1R,2'S)-1-(1'-Boc-2'-pyrrolidinyl)-2-(o,p-dibenzyloxyphenoxy)ethyl mesylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetone / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran / 20 °C

3: trialkyl amine / dichloromethane / 5 h / 20 °C

With sodium tetrahydroborate; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jm200937t