4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

Base Information

Chemical Name:4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine
CAS No.:1031246-43-1
Molecular Formula:C₁₅H₁₈FN₃O₂S
Molecular Weight:323.391
Hs Code.:

Synonyms:4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

Suppliers and Price of 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

Chemical Property:

Melting Point:138-139 °C
Boiling Point:474.4±47.0 °C(Predicted)
Density:1.270±0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

There total 6 articles about 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1031246-31-7
4-(4-fluorophenyl)-N-methyl-6-(1-methylethyl)-2-pyrimidinamine

: 124-63-0
methanesulfonyl chloride

: 1031246-43-1
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

Guidance literature:: 4-(4-fluorophenyl)-N-methyl-6-(1-methylethyl)-2-pyrimidinamine; With triethylamine; In dichloromethane; at 5 ℃; for 0.5h; Inert atmosphere;

methanesulfonyl chloride; In dichloromethane; at 0 - 25 ℃; for 12h; Temperature;

Reference yield: 30.0%

: 1031246-31-7
4-(4-fluorophenyl)-N-methyl-6-(1-methylethyl)-2-pyrimidinamine

: 124-63-0
methanesulfonyl chloride

: 1031246-43-1
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

: 4-(4-fluorophenyl)-6-isopropyl-N-methylpyrimidin-2-ylaminium methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 5h;
DOI:10.1002/ejoc.200700813

Reference yield:

: 147118-37-4
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

: 1031246-31-7
4-(4-fluorophenyl)-N-methyl-6-(1-methylethyl)-2-pyrimidinamine

: 1031246-43-1
4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methanesulfonyl)amino]pyrimidine

Guidance literature:: With 1.26 wt% Ni(0) nanospecies supported on CeO₂; In toluene; at 150 ℃; under 760.051 Torr; Inert atmosphere;
DOI:10.1021/acscatal.1c03375