3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionic acid

Base Information

Chemical Name:3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionic acid
CAS No.:935686-93-4
Molecular Formula:C₁₈H₁₅F₂NO₃
Molecular Weight:331.319
Hs Code.:

Synonyms:3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionic acid

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Technology Process of 3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionic acid

There total 1 articles about 3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 935686-92-3
4-Fluoro-2-(4-fluorobenzyl)-3-(3-hydroxypropyl)-2,3-dihydroisoindol-1-one

: 935686-93-4
3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionic acid

Guidance literature:: With Jones reagent; In acetone; at 0 - 20 ℃; for 2.5h;

Reference yield: 83.0%

: 3034-22-8
5-bromo-2-aminothiazole

: 935686-93-4
3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionic acid

: N-(5-Bromo-thiazol-2-yl)-3-[7-fluoro-2-(4-fluoro-benzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionamide

Guidance literature:: 3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 1.5h;

5-bromo-2-aminothiazole; With pyridine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield: 22.0%

: 935686-72-9
Trimethylsilyl 6-aminonicotinate

: 935686-93-4
3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionic acid

: 6-{3-[7-Fluoro-2-(4-fluoro-benzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionylamino}-nicotinic acid

Guidance literature:: 3-[7-Fluoro-2-(4-fluorobenzyl)-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-propionic acid; With triethylamine; HATU; In tetrahydrofuran; for 1.5h;

Trimethylsilyl 6-aminonicotinate; for 16h;