3034-22-8

Basic information

• Product Name: 2-Amino-5-bromothiazole
• Synonyms: TIMTEC-BB SBB000204;5-BROMO-THIAZOL-2-YLAMINE;2-AMINO-5-BROMOTHIAZOLE;5-bromo-1,3-thiazol-2-ylamine;5-BROMO-2-AMINOTHIAZOLE HYDROBROMIDE;2-Thiazolamine, 5-bromo-;2-AMINO-5-BROMO-1,3-THIAZOLE;5-Bromo-2-aminothiazole hydrobromide, HPLC 95%
• CAS NO: 3034-22-8
• Molecular Formula: C₃H₃BrN₂S
• Molecular Weight: 179.04
• EINECS: 262-699-0
• Product Categories: Sulphur Derivatives;Halides;Thiazoles, Isothiazoles &Benzothiazoles;Thiazoles;Thiazoles, Isothiazoles & Benzothiazoles;amine | alkyl bromide
• Mol File: 3034-22-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 165 °C (dec.)(lit.)
• Boiling Point: 287.6 °C at 760 mmHg
• Flash Point: 127.7 °C
• Appearance: /
• Density: 1.976 g/cm³
• Vapor Pressure: 0.00246mmHg at 25°C
• Refractive Index: 1.69
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 3.22±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-5-bromothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-bromothiazole(3034-22-8)
• EPA Substance Registry System: 2-Amino-5-bromothiazole(3034-22-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26-36/37
• RTECS: XJ1262200
• Hazardous Substances Data: 3034-22-8(Hazardous Substances Data)

Usage

General Description

2-Amino-5-bromothiazole is a chemical compound with the molecular formula C4H4BrN3S. It is a derivative of thiazole and contains an amino group and a bromine atom. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in organic synthesis and can be found in some research and development processes. 2-Amino-5-bromothiazole is known for its ability to participate in various chemical reactions, making it a versatile compound with a range of potential applications in different industries.

InChI:InChI=1/C3H3BrN2S/c4-2-1-6-3(5)7-2/h1H,(H2,5,6)

Upstream product

• 3034-56-8 5-bromo-2-chloro-1,3-thiazole 
• 226879-69-2 phenyl N-2-(5-bromothiazolyl)carbamate 
• 7336-54-1 2-acetamido-5-bromothiazole 
• 96-50-4 2-thiazolylamine 
• 61296-22-8 5-bromothiazol-2-amine hydrobromide 

Downstream Products

• 59278-80-7 5-phenylsulfanyl-thiazol-2-ylamine 
• 7336-54-1 2-acetamido-5-bromothiazole 
• 405939-39-1 tert-butyl 5-bromothiazol-2-ylcarbamate 
• 878376-02-4 5-(3-fluorophenoxy)-1,3-thiazol-2-amine 
• 878376-03-5 5-[(3-fluorobenzyl)thio]-1,3-thiazol-2-amine 
• 439578-97-9 5-(2-aminothiazol-5-yl)sulfanyl-2-methoxy-4-methylbenzoic acid 
• 439578-88-8 3-[(2-Aminothiazol-5-yl)thio]-4-methylbenzoic Acid Methyl Ester 
• 903568-20-7 5-(2-amino-thiazol-5-ylsulfanyl)-2,3-dimethyl-benzoic acid methyl ester 
• 439579-02-9 2-Amino-5-[(5-carbomethoxy-4-methoxy-2-methylphenyl)thio]thiazole 
• 903568-21-8 3-(2-amino-thiazol-5-ylsulfanyl)-4,5-dimethyl-benzoic acid methyl ester 
• 903568-22-9 5-(2-amino-thiazol-5-ylsulfanyl)-2,4-dimethyl-benzoic acid methyl ester 
• 903568-23-0 5-(2-amino-thiazol-5-ylsulfanyl)-2-hydroxy-4-methyl-benzoic acid methyl ester 
• 903568-17-2 2-acetylamino-5-(2-amino-thiazol-5-ylsulfanyl)-benzoic acid methyl ester 
• 903568-13-8 5-(2-amino-thiazol-5-ylsulfanyl)-2-chloro-benzoic acid methyl ester 

Relevant articles and documents

CYANOPYRROLIDINE DERVIVATIVES AS INHIBITORS FOR DUBS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of Cezanne 1 and ubiquitin C-terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of cancer. Compounds of the invention include compounds having the formula (I): pharmaceutically acceptable salt thereof, wherein R1a, R1b, R1c, R1d, R1e, R1f and A are as defined herein.

Synthesis of Brominated Thiazoles via Sequential Bromination-Debromination Methods

The synthesis of the full family of bromothiazoles has been revisited in order to update and optimize their production. The species reported include 2-bromothiazole, 4-bromothiazole, 5-bromothiazole, 2,4-dibromothiazole, 2,5-dibromothiazole, 4,5-dibromothiazole, and 2,4,5-tribromothiazole, the majority of which are produced via sequential bromination and debromination steps. This complete family can now be produced without the use of elemental bromine, and the presented methods have allowed the physical and NMR spectroscopic characterization of the full family to be reported for the first time.

THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY

The present invention relates to certain thiazolopyrimidinone compounds for use in modulating NMDA receptor activity, pharmaceutical compositions comprising such compounds and methods of treating neurological and psychiatric conditions.