3,10-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-[1]benzofurano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Base Information

Chemical Name:3,10-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-[1]benzofurano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one
CAS No.:200941-21-5
Molecular Formula:C₃₈H₄₃NO₉
Molecular Weight:657.761
Hs Code.:

Synonyms:3,10-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-[1]benzofurano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

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Chemical Property of 3,10-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-[1]benzofurano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

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Technology Process of 3,10-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-[1]benzofurano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

There total 23 articles about 3,10-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-[1]benzofurano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 917497-48-4
3-[2-(6-bromo-2-isopropoxy-3,4-dimethoxyphenyl)ethyl]-7-isopropoxy-1-(4-isopropoxy-3-methoxyphenyl)-8-methoxy-4-oxo-3H-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid

: 200941-21-5
3,10-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-[1]benzofurano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: With palladium diacetate; triethylamine; triphenylphosphine; In acetonitrile; at 100 ℃; for 5h;
DOI:10.1055/s-2006-950191

Reference yield:

: 5-Isopropoxy-2-[5-isopropoxy-2-(4-isopropoxy-3-methoxy-phenylethynyl)-4-methoxy-phenoxycarbonylmethyl]-6,7-dimethoxy-3,4-dihydro-isoquinolinium; iodide

: 200941-21-5
3,10-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-[1]benzofurano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 83 ℃; for 32h; Yield given;
DOI:10.1039/a705874h

Reference yield:

: 621-59-0
isovanillin

: 200941-21-5
3,10-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,11,12-trimethoxy-8,9-dihydro-6H-[1]benzofurano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Guidance literature:: Multi-step reaction with 8 steps

1: K₂CO₃ / dimethylformamide / 19 h / 18 °C

2: 93 percent / AgOCOCF₃, I₂ / CHCl₃ / 7 h / Heating

3: 1.) BuLi, ZnCl₂ / 2.) Pd(PPh₃)4 / 1.) THF, -78 deg C, 0.83 h; -78 to 18 deg C, 1 h, 2.) 18 deg C, 4 h

4: MCPBA, KHCO₃ / CH₂Cl₂ / 1 h / 18 °C

5: NH₃ / methanol / 1 h / 18 °C

6: 97 percent / DCC, DMAP / CH₂Cl₂ / 3 h / 18 °C

7: 1,2-dichloro-ethane / 7 h / 18 °C

8: Huenig's base / 1,2-dichloro-ethane / 32 h / 83 °C

With dmap; n-butyllithium; ammonia; iodine; silver trifluoroacetate; potassium carbonate; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1039/a705874h