1-[2-(6-bromo-2-isopropoxy-3,4-dimethoxyphenyl)ethyl]-3,4-bis(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid

Base Information

Chemical Name:1-[2-(6-bromo-2-isopropoxy-3,4-dimethoxyphenyl)ethyl]-3,4-bis(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid
CAS No.:917497-47-3
Molecular Formula:C₃₉H₄₆BrNO₁₁
Molecular Weight:784.698
Hs Code.:

Synonyms:1-[2-(6-bromo-2-isopropoxy-3,4-dimethoxyphenyl)ethyl]-3,4-bis(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid

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Chemical Property of 1-[2-(6-bromo-2-isopropoxy-3,4-dimethoxyphenyl)ethyl]-3,4-bis(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid

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Technology Process of 1-[2-(6-bromo-2-isopropoxy-3,4-dimethoxyphenyl)ethyl]-3,4-bis(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid

There total 8 articles about 1-[2-(6-bromo-2-isopropoxy-3,4-dimethoxyphenyl)ethyl]-3,4-bis(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917497-32-6
6-bromo-2-hydroxy-3,4-dimethoxybenzaldehyde

: 917497-47-3
1-[2-(6-bromo-2-isopropoxy-3,4-dimethoxyphenyl)ethyl]-3,4-bis(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / K₂CO₃ / dimethylformamide / 20 °C

2: 100 percent / NH₄OAc / 0.75 h / 100 °C

3: 97 percent / TMSCl; LiBH₄ / tetrahydrofuran / 6 h / Heating

4: 2.31 g / 4 Angstroem molecular sieves / tetrahydrofuran; hexane / 1.33 h / Heating

With lithium borohydride; chloro-trimethyl-silane; 4 A molecular sieve; ammonium acetate; potassium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-950191

Reference yield:

: C₉H₉BrO₄

: 917497-47-3
1-[2-(6-bromo-2-isopropoxy-3,4-dimethoxyphenyl)ethyl]-3,4-bis(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 5.91 g / aq. KOH / diethyl ether

2: 85 percent / TiCl₄ / CH₂Cl₂ / 4 h / 20 °C

3: 78 percent / K₂CO₃ / dimethylformamide / 20 °C

4: 100 percent / NH₄OAc / 0.75 h / 100 °C

5: 97 percent / TMSCl; LiBH₄ / tetrahydrofuran / 6 h / Heating

6: 2.31 g / 4 Angstroem molecular sieves / tetrahydrofuran; hexane / 1.33 h / Heating

With potassium hydroxide; lithium borohydride; chloro-trimethyl-silane; 4 A molecular sieve; ammonium acetate; titanium tetrachloride; potassium carbonate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2006-950191

Reference yield:

: 917497-34-8
(E)-6-bromo-β-nitro-2-isopropoxy-3,4-dimethoxystyrene

: 917497-47-3
1-[2-(6-bromo-2-isopropoxy-3,4-dimethoxyphenyl)ethyl]-3,4-bis(4-isopropoxy-3-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / TMSCl; LiBH₄ / tetrahydrofuran / 6 h / Heating

2: 2.31 g / 4 Angstroem molecular sieves / tetrahydrofuran; hexane / 1.33 h / Heating

With lithium borohydride; chloro-trimethyl-silane; 4 A molecular sieve; In tetrahydrofuran; hexane;
DOI:10.1055/s-2006-950191