Technology Process of ethyl 3-(4-cyanophenyl)-2-formylpropanoate
There total 3 articles about ethyl 3-(4-cyanophenyl)-2-formylpropanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere
2: formic acid; triethylamine / palladium 10% on activated carbon / water; ethyl acetate / 1 h / 90 °C / Inert atmosphere; Reflux
3: sodium hydride / 1,2-dimethoxyethane / 20 °C
With
formic acid; sodium hydride; triethylamine;
palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine;
In
1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide;
1: Heck Reaction;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 1 h / 110 °C / Inert atmosphere
2: formic acid; triethylamine / palladium 10% on activated carbon / water; ethyl acetate / 1 h / 90 °C / Inert atmosphere; Reflux
3: sodium hydride / 1,2-dimethoxyethane / 20 °C
With
formic acid; sodium hydride; triethylamine;
palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine;
In
1,2-dimethoxyethane; water; ethyl acetate; N,N-dimethyl-formamide;
1: Heck Reaction;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: formic acid; triethylamine / palladium 10% on activated carbon / water; ethyl acetate / 1 h / 90 °C / Inert atmosphere; Reflux
2: sodium hydride / 1,2-dimethoxyethane / 20 °C
With
formic acid; sodium hydride; triethylamine;
palladium 10% on activated carbon;
In
1,2-dimethoxyethane; water; ethyl acetate;
