3-fluoro-2-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-6-hydroxybenzonitrile

Base Information

Chemical Name:3-fluoro-2-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-6-hydroxybenzonitrile
CAS No.:1427408-17-0
Molecular Formula:C₂₀H₁₃F₃N₂O
Molecular Weight:354.331
Hs Code.:

Synonyms:3-fluoro-2-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-6-hydroxybenzonitrile

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Chemical Property of 3-fluoro-2-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-6-hydroxybenzonitrile

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Technology Process of 3-fluoro-2-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-6-hydroxybenzonitrile

There total 8 articles about 3-fluoro-2-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-6-hydroxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1427408-16-9
3-fluoro-2-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-6-methoxy-benzonitrile

: 1427408-17-0
3-fluoro-2-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-6-hydroxybenzonitrile

Guidance literature:: With boron tribromide; In dichloromethane;

Reference yield:

: 93777-26-5
5-bromo-2-fluorobenzaldehyde

: 1427408-17-0
3-fluoro-2-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-6-hydroxybenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol; N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

2: toluene / 4 h / Molecular sieve; Reflux

3: sodium tetrahydroborate / methanol / 2 h / 20 °C

4: boron tribromide / dichloromethane

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; potassium carbonate; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 189628-38-4
5-fluoro-2-methoxybenzonitrile

: 1427408-17-0
3-fluoro-2-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]-6-hydroxybenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1.5 h / -78 °C

1.2: 0.5 h

2.1: diphenyl phosphoryl azide; triethylamine / tetrahydrofuran / 3 h / 20 °C

2.2: 2 h / Reflux

3.1: toluene / 4 h / Molecular sieve; Reflux

4.1: sodium tetrahydroborate / methanol / 2 h / 20 °C

5.1: boron tribromide / dichloromethane

With sodium tetrahydroborate; n-butyllithium; diphenyl phosphoryl azide; boron tribromide; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;