5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine
CAS No.:799811-50-0
Molecular Formula:C₅₃H₅₀N₄O₈
Molecular Weight:871.002
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 799811-49-7
3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine

: 799811-50-0
5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1039/b402414a

Reference yield:

: 19694-02-1
Pyrene-1-carboxylic acid

: 799811-50-0
5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / CDI / CH₂Cl₂ / 20 °C

2: 81 percent / TBAF / tetrahydrofuran / 20 °C

With tetrabutyl ammonium fluoride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b402414a

Reference yield:

: 165306-22-9
1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 799811-50-0
5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂ / 20 °C

2: tetrahydrofuran / 50 °C

3: 75 percent / CDI / CH₂Cl₂ / 20 °C

4: 81 percent / TBAF / tetrahydrofuran / 20 °C

With pyridine; tetrabutyl ammonium fluoride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b402414a