165306-22-9

Downstream Products

• 799811-45-3 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-4'-C-piperazino-methylthymidine 
• 799811-47-5 5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine 
• 799811-50-0 5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine 
• 799811-46-4 3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(fluorenylmethoxycarbonyl)piperazino)methylthymidine 
• 799811-49-7 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-4'-C-(N-(pyren-1-ylcarbonyl)piperazino)methylthymidine 
• 642083-39-4 3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-4'-C-((4-methylpiperazino)methyl)thymidine 
• 642083-40-7 5'-O-(4,4'-dimethoxytrityl)-4'-C-((N-methylpiperazino)methyl)thymidine 

Relevant academic research and scientific papers

Synthesis of oligodeoxynucleotides containing 4'-C-(hydroxymethyl)thymidine: Novel promising antisense molecules

4'-C-(Hydroxymethyl)thymidine derivative 1 was transformed into phosphoramidite 7 which was used for incorporation of 4'-C-hydroxymethyl functionalized thymidine monomers once and twice into 17-mer oligodeoxynucleotides (ODNs). The novel modified ODNs exhibited excellent affinity towards complementary DNA and increased resistance towards 3'-exonucleolytic degradation compared to unmodified ODNs.