4-Benzyl-3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-4H-[1,2,4]triazole

Base Information

• Chemical Name: 4-Benzyl-3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-4H-[1,2,4]triazole
• CAS No.: 179055-99-3
• Molecular Formula: C₂₃H₃₁N₃OSi
• Molecular Weight: 393.604
• Mol file: 179055-99-3.mol

Synonyms:4-Benzyl-3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-4H-[1,2,4]triazole

Chemical Property of 4-Benzyl-3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-4H-[1,2,4]triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Benzyl-3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-4H-[1,2,4]triazole

There total 6 articles about 4-Benzyl-3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-4H-[1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

benzylamine (100-46-9) + 2-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-[1,3,4]oxadiazole (179055-97-1) → 4-Benzyl-3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-4H-[1,2,4]triazole (179055-99-3)

Guidance literature:

at 150 ℃; for 48h;

DOI:10.1021/jm9800853

Reference yield:

4-(methoxycarbonyl)benzyl alcohol (6908-41-4,58590-49-1) → 4-Benzyl-3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-4H-[1,2,4]triazole (179055-99-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature

2: 100 percent / H₂NNH₂*H₂O / ethanol / 1 h / Heating

3: 73 percent / Et₃N / ethanol / 0.5 h

4: 77 percent / 48 h / 150 °C

With 1H-imidazole; hydrazine hydrate; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm9800853

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 4-Benzyl-3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-4H-[1,2,4]triazole (179055-99-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature

2: 100 percent / H₂NNH₂*H₂O / ethanol / 1 h / Heating

3: 73 percent / Et₃N / ethanol / 0.5 h

4: 77 percent / 48 h / 150 °C

With 1H-imidazole; hydrazine hydrate; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm9800853

upstream raw materials:

benzylamine

2-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-[1,3,4]oxadiazole

4-(methoxycarbonyl)benzyl alcohol

tert-butyldimethylsilyl chloride

Downstream raw materials:

[4-(4-Benzyl-5-methyl-4H-[1,2,4]triazol-3-yl)-phenyl]-methanol

Cycloheptyl-[4-(5-methyl-4H-[1,2,4]triazol-3-yl)-benzyl]-amine

4-(4-Benzyl-5-methyl-4H-[1,2,4]triazol-3-yl)-benzaldehyde

[4-(4-Benzyl-5-methyl-4H-[1,2,4]triazol-3-yl)-benzyl]-cycloheptyl-amine