(E)-2-cyano-3-(dimethylamino)-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acrylamide

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Chemical Name:(E)-2-cyano-3-(dimethylamino)-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acrylamide
CAS No.:1297612-49-7
Molecular Formula:C₂₄H₂₁N₇O₂
Molecular Weight:439.476
Hs Code.:

Synonyms:(E)-2-cyano-3-(dimethylamino)-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acrylamide

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Chemical Property of (E)-2-cyano-3-(dimethylamino)-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acrylamide

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Technology Process of (E)-2-cyano-3-(dimethylamino)-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acrylamide

There total 5 articles about (E)-2-cyano-3-(dimethylamino)-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1297612-47-5
2-cyano-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acetamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1297612-49-7
(E)-2-cyano-3-(dimethylamino)-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acrylamide

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 0.0166667h; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.02.040

Reference yield:

: 1297612-44-2
3-(2-methyl-1H-indol-3-yl)-3-oxo-2-(phenylhydrazono)propanenitrile

: 1297612-49-7
(E)-2-cyano-3-(dimethylamino)-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / N,N-dimethyl-formamide / 0.02 h / 120 °C / Microwave irradiation

2: 0 h / 80 °C / Microwave irradiation; Neat (no solvent)

3: N,N-dimethyl-formamide / 0.02 h / 120 °C / Microwave irradiation

With hydroxylamine hydrochloride; sodium acetate; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.040

Reference yield:

: 76397-72-3
3-(2-methyl-1H-indol-3-yl)-3-oxopropanenitrile

: 1297612-49-7
(E)-2-cyano-3-(dimethylamino)-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 0 °C

1.2: 1 h / 20 °C

2.1: hydroxylamine hydrochloride; sodium acetate / N,N-dimethyl-formamide / 0.02 h / 120 °C / Microwave irradiation

3.1: 0 h / 80 °C / Microwave irradiation; Neat (no solvent)

4.1: N,N-dimethyl-formamide / 0.02 h / 120 °C / Microwave irradiation

With hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; sodium nitrite; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.040