N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-7-phenyl pyrazolo[1,5-a]pyrimidine-3-carboxamide

Base Information

Chemical Name:N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-7-phenyl pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:1297612-58-8
Molecular Formula:C₃₁H₂₂N₈O₂
Molecular Weight:538.568
Hs Code.:

Synonyms:N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-7-phenyl pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Property of N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-7-phenyl pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Technology Process of N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-7-phenyl pyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 8 articles about N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-7-phenyl pyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1201-93-0
1-phenyl-3-dimethylaminoprop-2-enone

: 1297612-53-3
5-amino-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-1H-pyrazole-4-carboxamide

: 1297612-58-8
N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-7-phenyl pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With pyridine; at 120 ℃; for 0.0333333h; Microwave irradiation;
DOI:10.1016/j.ejmech.2011.02.040

Reference yield:

: 1297612-49-7
(E)-2-cyano-3-(dimethylamino)-N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]acrylamide

: 1297612-58-8
N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-7-phenyl pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 0.25 h / Reflux

2: pyridine / 2 h / Reflux

3: pyridine / 0.03 h / 120 °C / Microwave irradiation

With pyridine; hydrazine hydrate; In ethanol;
DOI:10.1016/j.ejmech.2011.02.040

Reference yield:

: 1297612-44-2
3-(2-methyl-1H-indol-3-yl)-3-oxo-2-(phenylhydrazono)propanenitrile

: 1297612-58-8
N-[5-(2-methyl-1H-indole-3-carbonyl)-2-phenyl-2H-1,2,3-triazol-4-yl]-7-phenyl pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydroxylamine hydrochloride; sodium acetate / N,N-dimethyl-formamide / 0.02 h / 120 °C / Microwave irradiation

2: 0 h / 80 °C / Microwave irradiation; Neat (no solvent)

3: N,N-dimethyl-formamide / 0.02 h / 120 °C / Microwave irradiation

4: hydrazine hydrate / ethanol / 0.25 h / Reflux

5: pyridine / 2 h / Reflux

6: pyridine / 0.03 h / 120 °C / Microwave irradiation

With pyridine; hydroxylamine hydrochloride; sodium acetate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.040