4-methyl-7-(4-(methanesulfonyl)phenyl)-1-(naphthalen-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine L-tartrate

Base Information

Chemical Name:4-methyl-7-(4-(methanesulfonyl)phenyl)-1-(naphthalen-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine L-tartrate
CAS No.:1084742-76-6
Molecular Formula:C₄H₆O₆*C₂₇H₂₆N₂O₂S
Molecular Weight:592.67
Hs Code.:

Synonyms:4-methyl-7-(4-(methanesulfonyl)phenyl)-1-(naphthalen-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine L-tartrate

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Chemical Property of 4-methyl-7-(4-(methanesulfonyl)phenyl)-1-(naphthalen-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine L-tartrate

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Technology Process of 4-methyl-7-(4-(methanesulfonyl)phenyl)-1-(naphthalen-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine L-tartrate

There total 6 articles about 4-methyl-7-(4-(methanesulfonyl)phenyl)-1-(naphthalen-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine L-tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 87-69-4,138508-61-9
L-Tartaric acid

: 1084742-75-5
4-methyl-7-(4-(methanesulfonyl)phenyl)-1-(naphthalen-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine

: 1084742-76-6
4-methyl-7-(4-(methanesulfonyl)phenyl)-1-(naphthalen-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine L-tartrate

Guidance literature:: In methanol; water;

Reference yield:

: 118-48-9
isatoic anhydride

: 1084742-76-6
4-methyl-7-(4-(methanesulfonyl)phenyl)-1-(naphthalen-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine L-tartrate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 7 h / Heating / reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 7 h / 0 °C / Heating / reflux

2.2: 1 h / 20 °C

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 0 °C

4.1: caesium carbonate / palladium diacetate; XPhos / toluene / Heating / reflux

5.1: potassium hydroxide; potassium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 110 °C

6.1: methanol; water

With pyridine; potassium hydroxide; N-Bromosuccinimide; lithium aluminium tetrahydride; caesium carbonate; potassium bromide; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1084743-67-8
C₁₀H₁₃BrN₂

: 1084742-76-6
4-methyl-7-(4-(methanesulfonyl)phenyl)-1-(naphthalen-2-yl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine L-tartrate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / palladium diacetate; XPhos / toluene / Heating / reflux

2: potassium hydroxide; potassium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 110 °C

3: methanol; water

With potassium hydroxide; caesium carbonate; potassium bromide; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; XPhos; In methanol; water; toluene;