4-Methyl-benzenesulfinic acid ((S)-1-[1,3]dithian-2-yl-2,2-dimethyl-propyl)-amide

Base Information

• Chemical Name: 4-Methyl-benzenesulfinic acid ((S)-1-[1,3]dithian-2-yl-2,2-dimethyl-propyl)-amide
• CAS No.: 887113-31-7
• Molecular Formula: C₁₆H₂₅NOS₃
• Molecular Weight: 343.579

Synonyms:4-Methyl-benzenesulfinic acid ((S)-1-[1,3]dithian-2-yl-2,2-dimethyl-propyl)-amide

Chemical Property of 4-Methyl-benzenesulfinic acid ((S)-1-[1,3]dithian-2-yl-2,2-dimethyl-propyl)-amide

Chemical Property:

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Technology Process of 4-Methyl-benzenesulfinic acid ((S)-1-[1,3]dithian-2-yl-2,2-dimethyl-propyl)-amide

There total 2 articles about 4-Methyl-benzenesulfinic acid ((S)-1-[1,3]dithian-2-yl-2,2-dimethyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1,3 dithiane (505-23-7) + (S)-(+)-(2,2-dimethylpropylidene)-p-toluenesulfinamide (174464-94-9) → 4-Methyl-benzenesulfinic acid ((S)-1-[1,3]dithian-2-yl-2,2-dimethyl-propyl)-amide (887113-31-7)

Guidance literature:

1,3 dithiane; With n-butyllithium; In tetrahydrofuran; hexane; at -20 ℃; Inert atmosphere;

(S)-(+)-(2,2-dimethylpropylidene)-p-toluenesulfinamide; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.3998/ark.5550190.0011.804

Reference yield: 72.0%

2-lithio-1,3-dithiane (36049-90-8) + (S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide (188447-86-1) → 4-Methyl-benzenesulfinic acid ((S)-1-[1,3]dithian-2-yl-2,2-dimethyl-propyl)-amide (887113-31-7)

Guidance literature:

In tetrahydrofuran; at -78 ℃;

DOI:10.1016/j.tetlet.2006.02.092

Reference yield:

4-Methyl-benzenesulfinic acid ((S)-1-[1,3]dithian-2-yl-2,2-dimethyl-propyl)-amide (887113-31-7) → N-(1-formyl-2,2-dimethyl-propyl)-4-methyl-benzenesulfonamide (887255-42-7)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione;

DOI:10.1016/j.tetlet.2006.02.092

upstream raw materials:

2-lithio-1,3-dithiane

(S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide

1,3 dithiane

(S)-(+)-(2,2-dimethylpropylidene)-p-toluenesulfinamide

Downstream raw materials:

N-(1-formyl-2,2-dimethyl-propyl)-4-methyl-benzenesulfonamide

(S)-(+)-N-(1-hydroxymethyl-2,2-dimethylpropyl)-4-methylbenzenesulfonamide

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