(S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide

Base Information

• Chemical Name: (S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide
• CAS No.: 188447-86-1
• Molecular Formula: C₁₂H₁₇NOS
• Molecular Weight: 223.339
• Mol file: 188447-86-1.mol

Synonyms:(S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide

Chemical Property of (S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide

There total 2 articles about (S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

pivalaldehyde (630-19-3) + (S)-p-toluenesulfinimide (188447-91-8) → (S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide (188447-86-1)

Guidance literature:

With ytterbium(III) triflate; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1021/jo048597e

Reference yield: 61.0%

(-)-menthyl p-toluenesulfinate (1517-82-4) + pivalaldehyde (630-19-3) → (S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide (188447-86-1)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; Product distribution; effect of the presence of KF;

DOI:10.1021/jo970077e

Reference yield: 96.0%

acetic acid methyl ester (79-20-9) + (S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide (188447-86-1) → methyl (SS,R)-(+)-4,4-dimethyl-N-(p-toluenesulfinyl)-3-aminopentanoate (569352-10-9)

Guidance literature:

acetic acid methyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;

(S)-4-methyl-benzenesulfinic acid (2,2-dimethyl-propylidene)-amide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;

DOI:10.1021/jo030081s

upstream raw materials:

(-)-menthyl p-toluenesulfinate

pivalaldehyde

(S)-p-toluenesulfinimide

Downstream raw materials:

methyl (S_S,R)-(+)-4,4-dimethyl-N-(p-toluenesulfinyl)-3-aminopentanoate

4-tolyl thiocyanate

(Ss,3R)-(+)-3-(p-toluenesulfinylamino)-N-methoxy-N-methyl-3-tert-butylpropionamide

4-Methyl-benzenesulfinic acid ((S)-1-[1,3]dithian-2-yl-2,2-dimethyl-propyl)-amide