methyl N²-(4-methoxytrityl)-amino-6-chloropurin-9-yl acetate

Base Information

• Chemical Name: methyl N²-(4-methoxytrityl)-amino-6-chloropurin-9-yl acetate
• CAS No.: 172405-47-9
• Molecular Formula: C₂₈H₂₄ClN₅O₃
• Molecular Weight: 513.983
• Mol file: 172405-47-9.mol

Synonyms:methyl N²-(4-methoxytrityl)-amino-6-chloropurin-9-yl acetate

Chemical Property of methyl N²-(4-methoxytrityl)-amino-6-chloropurin-9-yl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N²-(4-methoxytrityl)-amino-6-chloropurin-9-yl acetate

There total 2 articles about methyl N²-(4-methoxytrityl)-amino-6-chloropurin-9-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methyl 2-(2-amino-6-chloro-9H-purin-9-yl)acetate (172405-46-8) + mono-4-methoxytrityl chloride (14470-28-1) → methyl N2-(4-methoxytrityl)-amino-6-chloropurin-9-yl acetate (172405-47-9)

Guidance literature:

With triethylamine; In pyridine;

DOI:10.1016/0960-894X(96)00082-0

Reference yield:

2-Amino-6-chloropurin (10310-21-1) → methyl N2-(4-methoxytrityl)-amino-6-chloropurin-9-yl acetate (172405-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NaH / dimethylformamide / 4 h

2: 60 percent / N,N-diisopropyl-N-ethylamine / tetrahydrofuran / 12 h

With sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2005.06.003

Reference yield: 85.0%

methyl N2-(4-methoxytrityl)-amino-6-chloropurin-9-yl acetate (172405-47-9) → [N2-(4-methoxytrityl)-guanin-9-yl]-acetic acid (172405-48-0)

Guidance literature:

With sodium hydroxide; for 3h; Heating;

DOI:10.1016/0960-894X(96)00082-0

upstream raw materials:

methyl 2-(2-amino-6-chloro-9H-purin-9-yl)acetate

mono-4-methoxytrityl chloride

2-Amino-6-chloropurin

Downstream raw materials:

[N²-(4-methoxytrityl)-guanin-9-yl]-acetic acid

{{2-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-ethyl}-[2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-yl)-acetyl]-amino}-acetic acid

{{2-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-ethyl}-[2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-yl)-acetyl]-amino}-acetic acid methyl ester

{[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethyl]-[2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-yl)-acetyl]-amino}-acetic acid