3-phenylacetamidonocardicinic acid

Base Information

• Chemical Name: 3-phenylacetamidonocardicinic acid
• CAS No.: 121719-55-9
• Molecular Formula: C₁₉H₁₈N₂O₅
• Molecular Weight: 354.362
• Mol file: 121719-55-9.mol

Synonyms:3-phenylacetamidonocardicinic acid

Chemical Property of 3-phenylacetamidonocardicinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-phenylacetamidonocardicinic acid

There total 4 articles about 3-phenylacetamidonocardicinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3-aminonocardicinic acid hydrochloride (67509-41-5) + phenylacetyl chloride (103-80-0) → 3-phenylacetamidonocardicinic acid (121719-55-9)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; at -5 ℃; for 2h;

DOI:10.1248/cpb.35.3979

Reference yield:

nocardicin A sodium salt (61425-19-2,61425-20-5,73618-22-1,75261-15-3) → 3-phenylacetamidonocardicinic acid (121719-55-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 84.8 percent / H₂ / Pd-C (10percent)

2: 78.1 percent / H₂O; pyridine / 1 h / Ambient temperature; pH 9

3: 40 percent / concd. HCl / acetic acid / 0.5 h / 10 °C

4: 69 percent / NaHCO₃ / acetone; H₂O / 2 h / -5 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In pyridine; water; acetic acid; acetone;

DOI:10.1248/cpb.35.3979

Reference yield:

nocardicin C (59511-12-5,75283-26-0,99297-17-3,99297-18-4) → 3-phenylacetamidonocardicinic acid (121719-55-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 78.1 percent / H₂O; pyridine / 1 h / Ambient temperature; pH 9

2: 40 percent / concd. HCl / acetic acid / 0.5 h / 10 °C

3: 69 percent / NaHCO₃ / acetone; H₂O / 2 h / -5 °C

With hydrogenchloride; sodium hydrogencarbonate; In pyridine; water; acetic acid; acetone;

DOI:10.1248/cpb.35.3979

upstream raw materials:

3-aminonocardicinic acid hydrochloride

phenylacetyl chloride

nocardicin C

bis(phenylthioureido)nocardicin C

Refernces